Liver metastases of gastric cancer

Nakagawa H, Kobayashi K, Tone T, Fukuda K, Shinn E, Mishima H, Yagyu T, Kobayashi T, Kikkawa N. [Combination of intra-hepatic arterial infusion of low-dose cisplatin and oral administration of high-dose doxyfluridine for patients with liver metastases of gastric cancer.] Gan To Kagaku Ryoho 1996 23(6) 783-5. 

Sakamoto Y, Ohyama S, Yamamoto J et al (2003) Surgical resection of liver metastases of gastric cancer an analysis of a 17-year experience with 22 patients. Surgery 133 507-511... 

Imaging During Therapy 154 Clinical Data of MR-Guided LITT of Liver Metastases 155 Results and Prognostic Factors of Liver Metastases of Colorectal Carcinoma 157 Liver Metastases of Breast Cancer 160 Liver Metastases of Gastric Cancer 161 Liver Metastases of Pancreatic Cancer 161 References 163... 

Local ablation of liver metastases of gastric cancer using MR-guided LITT is a safe, minimally invasive treatment option in well selected cases. 

Inoue Y et al. (1994) Hypervascular liver metastases of gastric cancer completely responding to transcatheter oily chemoembolization using epirubicin hydrochloride, mitomycin C and lipiodol. Gan To Kagaku Ryoho 21 1665-1667... 

Sensitivity, specificity, and predictive value of laparoscopy for the staging of gastric cancer and for the detection of liver metastases. Cancer 1986 58 1-6... 

With the exception of gastric cancer, surgical results for gastrointestinal primaries remain disappointing. Although pancreatic adenocarcinoma frequently metastasizes to the liver, hepatic resection for this disease has never been shown to result in a survival benefit [39]. 

Systemic chemotherapy is usually not indicated in non-colorectal liver metastases due to lack of response. The systemic administration of cytostatics (also in combination) possesses the status of palliative therapy. However, in metastatic neuroendocrine tumours, a combination of octreotide -i- IFN had a positive effect on the survival time. Systemic chemotherapy produced remission rates of up to 60%. (320) In metastatic breast cancer, systemic chemotherapy is indicated, usually in combination with hormonal and immune therapy. (316, 342) In metastatic gastric carcinoma, palliative chemotherapy can achieve a remission rate of up to 40%, with a slight extension of survival time. 

Fukui, R., H. Nishimori, F. Hata, T. Yasoshima, K. Ohno, H. Nomura, Y. Yanai, H. Tanaka, K. Kamiguchi, R. Denno, N. Sato, and K. Hirata. 2005. Metastases-related genes in the classification of liver and peritoneal metastasis in human gastric cancer. J Surg Res 129 94. 

Spectral Doppler measurements of hepatic arterial and portal venous blood flows are used for calculation of the DPI, i.e. ratio of hepatic arterial flow to total liver flow. In normal subjects the DPI is 0.25 (the hepatic artery contributes <25% of total liver blood flow), but this increases in arterialisation due to metastases. An excellent correlation between raised DPI and overt metastatic disease has been documented in colon and gastric cancer. In colon cancer patients with no overt liver malignancy, a raised DPI preoperatively correlated strongly with a shorter disease free survival and development of overtliver metastases within 5 years postoperatively, indicative of occult disease at presentation (Leen et... 

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