Liver disease vascular abnormalities

Monocytosis (>800/mm of blood) occurs with some infections (e.g., tuberculosis, histoplasmosis, toxoplasmosis, bacterial endocarditis, and salmonellosis), collagen vascular diseases (rheumatoid arthritis and systematic lupus erythematosus), gastrointestinal disorders (ulcerative cohtis and alcoholic liver disease), leukemias, and up to 60% of nonhematologic malignancies, whereas abnormally low monocyte concentrations occur in patients with hairy cell leukemia or aplastic anemia." ... 

Apigenin-7-glucoside and luteolin-7-glucoside are two flavones present in relatively large amounts in olive leaves that possess healthy effects. Thus, the former is used to fight Alzheimer s [244] and liver diseases [56], and the latter to avoid the abnormal proliferation of aortic vascular smooth muscle cells, which is a frequent cause of pathogenesis such as atherosclerosis and restenosis [245]. 

Pazderova examined Czech workers about ten years after exposure and found sustained neural and psychiatric problems and arteriosclerosis in the Czech workers, as well as glucose intolerance and increases in cholesterol (55). In a laboratory study of British workers ten years after exposure, Martin found increases in some liver enzymes as well as increased levels of cholesterol and triglycerides in exposed workers (56). Whether a health risk results from the enzyme and lipid changes is not known, but one concern is that lipid abnormalities may confer increased risk of coronary vascular disease. 

Contraindications History of thromboembohc disorders, deep venous thrombosis, cerebral vascular disease, myocardial infarction, liver cancer, estrogen-dependent cancer, breast cancer, undiagnosed abnormal genital bleeding, or suspected pregnancy. 

In 1974, Lange et al. reported of a systemic form of VC disease. Changes included skin sclerosis, pulmonary fibrosis, fibrosis of the liver and spleen, and disturbances in the capillary vascular system, joints, and musculature. Further manifestations are paresthesia, thrombocytopenia, leukopenia, and splenomegaly (Bachner et al. 1974). Capillary microscopy reveals that abnormalities of the nail-fold in VC workers are similar but less pronounced than those found in SSc (Maricq et al. 1976). Distal pitting scars, esophageal... 

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