Breast milk lithium

Lithium can cause hypotonicity and cyanosis in the neonate, usually termed the floppy baby syndrome. Most data indicate normal neurobehavioral development once these symptoms resolve. Lithium is readily transferred via breast milk. Breast-feeding is not advised for patients who are taking lithium.30... 

Lactation Lithium is excreted in breast milk. Do not nurse during lithium therapy. Children Safety and efficacy for use in children younger than 12 years of age have not been established. 

Lithium enters breast milk in concentrations equal to those in maternal serum. Clearance of this drug is almost completely dependent upon renal elimination, and women who are receiving lithium may expose the infant to relatively large amounts of the drug. 

Breast-milk lithium concentrations were measured in 11 women taking lithium carbonate 600-1,500 mg/day (506). Maternal serum concentrations were available in only three and infant concentrations in two. No infants had adverse effects that could be attributed to lithium, and the authors calculated that infant lithium exposure was low, leading them to challenge the general contraindication to breastfeeding under such circumstances. 

Some drug is found in mother s breast milk, possibly at full therapeutic levels since lithium Is soluble In breast milk... 

Lithium concentrations in breast milk are about 40% of maternal serum concentrations, although the range is... 

Moretti ME, Keren G, Verjee Z, Ito S. Monitoring lithium in breast milk an individualized approach for breast-feeding mothers. Ther Drug Monit 2003 25(3) 364-6. 

Ingestion is the most common exposure pathway lithium carbonate is administered orally. Occupational exposures to lithium rarely produce toxicity. Lithium occurs in breast milk of nursing women. 

Lithium is excreted into breast milk and so breast-feeding is not advised. 

Safety through the Life Cycle Most antidepressants appear to be safe during pregnancy. Most antidepressants and lithium are secreted in breast milk, at least in small quantities, and their safety in nursing infants is neither established nor safely assumed. For severe depression during pregnancy and lactation, EOT can be a relatively safe and effective alternative. 

Breast milk Lithium levels were measured in four breast-fed infants delivered to three women who remained on lithium throughout the pregnancy and breast feeding period [125 Infant lithium levels at one month ranged from 10% to 17% of maternal levels (0.08-0.11 mM vs maternal levels of 0.48-0.97mM) [125 ... 

Lithium Significant Breast-feeding with caution levels can be measured in milk. 

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