Lipoxins stable analog

Serhan CN, Levy BD, Clish CB, Gronert K, Chiang N. Lipoxins, aspirin-triggered 15-epi-lipoxin stable analogs and their receptors in anti-inflammation a window for therapeutic opportunity. Ernst Sobering Res. Found Workshop 2000 143-185. 

Maddox JE, Hachicha M, Takano T, Petasis NA, Fokin VV, Serhan CN (1997) Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. J Biol Chem 272 6972—6978... 

Maddox JE, Colgan SP, CUsh CB, Petasis NA, Fokin VV, Serhan CN (1998) Lipoxin B4 regulates human monocyte/neutrophil adherence and motility design of stable lipoxin B4 analogs with increased biologic activity. FASEB J 12 487 94... 

Scalia R, Gefen J, Petasis NA, Serhan CN, Lefer AM (1997) Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature role of P-selectin. Proc Natl Acad Sci USA 94 9967-9972... 

Serhan CN. Maddox JF, Petasis NA, Akritopoulou-Zanze I, Papayianni A, Brady HR, Colgan SP, Madara JL (1995) Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochetuistry 34 14609-14615... 

Takano T, Fiore S, Maddox JF, Brady HR, Petasis NA, Serhan CN Aspirin-triggered 15-epi-lipoxin A4 and LXA4 stable analogs are potent inhibitors of acute inflammation Evidence for antiinflammatory receptors. J Exp Med 1997 185 1693-1704. 

Filep JG, Zouki C, Petasis NA, Hachicha M, Serhan CN Anti-inflammatory actions of lipoxin A4 stable analogs are demonstrable in human whole blood Modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions. Blood 1999 94 4132-4142. 

Investigations on the actions of lipoxins in various cell types and in vivo, helped to establish these lipid mediators as immunomodulators that exhibit potent antiinflammatory and pro-resolving actions. In addition to reducing excessive and persistent inflammation, LXA4 and its synthetic stable analogs were the first molecules... 

A large number of studies on the biological actions of the lipoxins and their stable analogs revealed the multi-faceted biological roles of this class of lipid mediators [8,10,11,27,28,30,31,35,37-63], Selected examples of applications in various disease models are summarized in the section Beneficial Roles of Lipoxins, Resolvins, Protectins, and Maresins (Table 9.1). 

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