Liposomal drug effect

RES-Avoiding Liposomes. Since intravenously administered liposomes tend to accumulate in the RES, liposomal drugs work effectively when the target site is the RES. On the other hand, when the target site is not the RES, liposomal uptake by RES should be avoided. Liposomes that are not recognized by the RES have... 

Niosomes (prepared using surfactant I and surfactant I, II, or III and 30% cholesterol) containing stibogluconate have been as effective as the corresponding liposomal drugs in the visceral leishmaniasis model. Free drug showed reduced efficacy [169],... 

The general outcome of these studies was that the liposomal drugs were well tolerated and exerted a clinical effect, although larger studies need to be carried out to demonstrate the extent of the effects. Furthermore, in the various studies of liposome-incorporated drugs, it was observed that cardiotoxicity was either absent or only limited, in contrast to studies with non-liposomally formulated drugs. 

Katayama, K., et al. 2003. Double liposomes Hypoglycemic effects of liposomal insulin on normal rats. Drug Dev Ind Pharm 29 725. 

Foldvari, M., Effect of vehicle on topical liposomal drug delivery petrolatum bases, J. Microencapsul., 13, 589, 1996. 

Activation, dextran and inulin, 189-195 Activation energy of diffusion, 50-52 Additives, effect on percutaneous absorption of drugs in rabbits, 275 Agarose gel, use in liposomal drug delivery system, 267-270 Albumin microspheres intramuscular and intraarticular drug delivery, 204,206,211 preparation, 204,207/... 

Various colloidal systems have been studied for use as potential ophthalmic delivery systems, including liposomes and nanoparticles. Liposomes are bioerodible and biocompatible systems consisting of microscopic vesicles composed of lipid bilayers surrounding aqueous compartments. Liposomes have demonstrated prolonged drug effect at the site of action but with reduced toxicity. Ophthalmic studies have included topical, subconjunctival, and intravitreal administration, but no commercial preparations are currently available for ophthalmic use. 

Vemuri S, Yu CD, DeGroot JS, et al. Effect of sugars on freeze-thaw and lyophilisation of liposomes. Drug Dev Ind Pharm 1991 17(3) 327-348. 

Effect of Temperature on Liposomal Drug Release and Absorption by SPLA2... 

Maruyama, K. Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effects. Adv. Drug Deliv. Rev. 2011, 63 (3), 161-169. 

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