Lipids in yeasts

Czabany, T., Athenstaedt, K., and Daum, G. (2007) Synthesis, storage and degradation of neutral lipids in yeast. Biochim. Biophys. Acta, 1771, 299-309. 

The synthesis of lipids in yeasts has recently been reviewed with particular emphasis on commercial aspects, that is production of triacyl-... 

Davies, R.J. and Holdsworth, J.E. (1992) Synthesis of lipids in yeasts biochemistry, physiology, production. Adv. Appl. Lipid Res. 1, 119-159. 

It should be recognized that although much of the fundamental metabolism of lipids in yeast is similar to that in mammalian cells, there exist some key differences between the yeast and mammalian cells. For example,... 

Henry S.A. (1982) Membrane lipids of yeast biochemical mid genetic studies. In The Molecular Biology of the Yeast Saccharomyces, vol. 2. Metabolism and Biosynthesis (eds J.N. Strathem, E.W. Jones J.R. Broach), pp. 101-158. Cold Spring Harbor, NY Cold Spring Harbor Laboratory. 

So far GPI biosynthesis raises many questions as its correct regulation is crucial for viability in yeast and for embryonic development in mammals. Many steps remain unclear, also due to the fact that most of the proteins involved still have to be characterized. The same is true for the biological function of the GPI anchor apart from membrane insertion. Several suggestions have been made according to which GPI anchors are targeting lipid rafts, specific intracellular compartments, or the apical membrane of polarized epithelial cells. 

FIGURE 21-8 Subcellular localization of lipid metabolism. Yeast and vertebrate cells differ from higher plant cells in the compartmentation of lipid metabolism. Fatty acid synthesis takes place in the compart-... 

Triglycerides, lecithin, and ergosterol are the main constituents of yeast lipid (feu. Oleic and palmitic acids predominate in yeast fet. These resemble the composition of common vegetable fats. Ergosterol. the precursor of calciferol (vitamin D2) varies from 1 to 3% of yeast dry matter. 

Pueyo, E., Marti nez-Rodriguez, A., Polo, M. C., Santa-Maria, G., and Bartolome, B. (2000). Release of lipids during yeast autolysis in a model wine system. ]. Agric. Food Chem. 48, 116-122. 

Offenbacher EG, Pi-Sunyer FX. 1980. Beneficial effect of chromium-rich yeast on glucose tolerance and blood lipids in elderly subjects. Diabetes 29 919-925. 

Paltauf, F., Kohlwein, S., and Henry, S.A., 1992, Regulation and compartmentalization of lipid synthesis in yeast. In Pringle, J. (ed.), The Molecular and Cellular Biology of the Yeast Saccharomyces. Cold Spring Harbor Laboratory Press, Plainview, NY, USA, pp. 415-500. 

Sreenivas, A., Patton-Vogt, J.L., Bruno, V, Griac, P., and Henry, S.A., 1998, A role for phospholipase D (Pldlp) in growth, secretion, and regulation of membrane lipid synthesis in yeast. J. Biol. Chem. 273 16635-16638. 

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