Self-assembly lipids

Mulet, X. and Drummond, C.J. (2011) Anandamide andanalogous endocannabinoids a lipid self-assembly study. Soft Matter, 7, 5319—5328. 

T. Delclos, C. Aime, E. Pouget, A. Brizard, I. Hue, M.-H. Delville and R. Oda, Individualized Silica Nanohelices and Nanotubes Tuning Inorganic Nanostructures Using Lipidic Self-Assemblies, Nano Lett., 2008, 8, 1929. 

New theory will be required to describe the phase diagram of block liposomes. In particular, theories have to break new ground in explaining why nanorods and nanotubes stay attached to spherical vesicles. All current theories of lipid self-assemblies (based on Helffich s theory of membranes [98]), in contrast, predict spherical, tubular, and micellar shaped liposomes but only as separate objects. In our experiments, not a single instance of an isolated rod- or tube-shaped liposome (i.e., not connected to a sphere- or pear-shaped vesicle) was found. 

Chap ter 5 Lipid Self-Assembly and Fimction In Biological Systems... 

V. Effect of OA and Its Counterparts on Lipidic Self-Assembled Nanostructures... 

Lipid self-assembly and the lipid bilayer membrane... 

FIGURE 1.40 Different lipid self-assembly monolayer (SAM) structures (a) micelle (b) monolayer (c) LB film and (d) vesicle. 

The inherent lipid self-assembly characteristic is the main driving force in these structures. Monolayer studies are the only source of data which provides direct estimation of the stabilizing forces. Hence, it is safe to conclude that many important natural systems are based upon this molecular characteristics of lipids. Vesicles are unilamellar phospholipid liposome. 

Apart from micelles, surfactants, block copolymers and polar lipids self-assemble to a wide range of liquid crystalline phases and microemulsions [Ij. These systems offer opportunities for increased solubilization of hydrophobic drugs. Similarly, due to their water compartments, some liquid crystalline phases (e.g. cubic) are also interesting delivery systems for proteins, peptides and other biomolecular drugs. Depending on its physicochemical properties, a drug incorporated in such self-assembly systems may localize preferentially in the oil or water compartment(s), or at the interface between these, thereby affecting the structure and stability of the self-assembled system. 

Lipid Self-Assembly, a Water-Driven Glial Cells and Neurons ... 

LIPID SELF-ASSEMBLY, A WATER-DRIVEN PROCESS ... 

Surfactant and lipid self-assembly can lead to a diverse range of aggregate structures, the type of aggregate formed being mainly determined by the chemical structure and the relative strength of the hydrophilic and lipophilic parts [49]. 

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