Lignocaine hydrochloride

Organic Substances Cephalexin, Lignocaine hydrochloride, Griseofulvin, Diazoxide, Medazapam, Saccharin. 

Dose. For local anaesthesia, the total dose of lignocaine hydrochloride by injection should not exceed 300 mg (4.5 mg/kg), unless administered with adrenaline. For ventricular arrhythmias, initally 50 to 100 mg intravenously, followed by an infusion. 

LIDOCAINE HYDROCHLORIDE LIDOTHESIN HYDROCHLORIDE LIGNOCAINE HYDROCHLORIDE RUCAINA HYDROCHLORIDE S 202 XYCAINE HYDROCHLORIDE XYLESTESIN HYDROCHLORIDE XYLOCAINE HYDROCHLORIDE... 

Examples Lignocaine Hydrochloride Prilocaine Hydrochloride Mepivacaine Hydrochloride Bupivacaine Hydrochloride Pyrrocaine Hydrochloride Diperodon. 

A. Lignocaine Hydrochloride BAN, Lidocaine INN, Lidocaine Hydrochloride USAN. 

Chloroacetoxylidide is prepared by the interaetion of 2, 6-xylidine with chloroacetyl chloride which on treatment with diethylamine yields the lignoeaine base. This when treated with an equimolar quantity of hydrochloric acid gives the respeetive lignocaine hydrochloride. 

Fig. 5. a Chemical structure of procaine hydrochloride, 2-diethylaminoethyl-4-aminoben-zoate hydrochloride, an ester local anaesthetic, b Structure of lignocaine hydrochloride, iV-diethylaminoacetyl-2,6-xylidine hydrochloride monohydrate, an amide local anaesthetic... 

Cationic lidocaine (lignocaine) hydrochloride is commonly assumed to be incompatible with anionic sodium heparin.The possibility of interac-... 

Two methods which are quite widely applicable to many local anaesthetics are non-aqueous titration (perchloric acid to crystal violet, p. 792) and titration with sodium nitrite (0 5 g in 75 ml water and 10 ml hydrochloric acid, titrating with O IM nitrite and determining the end-point using the dead-stop technique, p. 867). A few materials such as benzocaine may be determined by both methods but in most cases either one or the other is applicable. Lignocaine hydrochloride, for example, gives a satisfactory end-point by the non-aqueous method but cannot be determined by titration with nitrite procaine hydrochloride on the other hand is satisfactorily titrated wdth nitrite but gives rise to a precipitate during titration in non-aqueous medium which obscures the end-point. Certain compounds such as amethocaine hydrochloride cannot be determined by either method. 

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