Light fluorous reagents

Curran, D. P. (2006) Organic synthesis with light-fluorous reagents, reactants, catalysts, and... 

Zhang Q, Luo Z, Curran DP (2000) Separation of Light Fluorous reagents and catdysts by fluorous solid-phase extraction synthesis and study of a femily of Triarylphosphines bearing linear and branched fluorous tags. J Org Chem 65 8866-8873... 

As chemical synthesis moves from discovery to production, scales increase and the use of catalytic rather than stoichiometric quantities of reagents is increasingly advantageous from both the economic and environmental standpoints. The vast majority of fluorous catalysts prepared to date are best classified as heavy fluorous catalysts, and they are removed from the reaction mixture by liquid/liquid separation techniques. On the one hand, fluorous silica gel provides another option for these catalysts, which is to use a solid/liquid separation instead. On the other hand, fluorous silica gel enables the use of light fluorous catalysts, such as the palladium catalyst shown in Scheme 36. Mizoroki-Heck reactions are promoted by standard conductive heating (oil bath) or microwave heating. After cooling and solid-phase extraction. 

The introduction and subsequent commercialization of fluorous silica gel have enabled the light branch of fluorous chemistry. The applicability of this chemistry covers all types of reaction components (substrates, reagents, reactants, catalysts, scavengers) and cuts across the synthesis spectrum from small-scale discovery... 

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