Licorice root, constituents

Kitagawa, I. et al.. Chemical studies of Chinese licorice-roots. I. Elucidation of five new flavonoid constituents from the roots of Glycyrrhiza glabra collected in Xinjiang, Chem. Pharm. Bull., 42, 1056, 1994. 

Hatano T, Kagawa H, Yasuhara T, Okuda T. Two new flavonoids and other constituents in licorice root their relative astringency and radical scavenging effects. Chemical Pharmaceulical Bulletin. 1988 36(6) 2090-2097. 

Extracts of licorice root have also been used as a flavoring agent. Hlraga et al. (4 ) among others have developed an HPLC separation for the constituents in licorice. Because the numerous components in licorice vary considerably 1n polarity, a reverse phase C-18 column with a water/acetonitrlle gradient was employed. Nineteen components were identified. However, a three hour extraction coupled to the 60 m1n. analysis time probably makes this procedure too lengthy for routine use. 

Shibata, S., and T Saitoh The Chemical Constituents of Licorice Roots. Taisha (Metabolism Disease, Japan), 10, 619 (1973) Chem. Abstr., 81, 101792n (1974). 

Kitagawa, L, and K. Hori Chemical Constituents of Licorice-Roots. Gendai Toyo Igaku (J. Traditional Sino-Japanese Med., Japan), 14, 80 (1993). 

Shibata, S., and T. Saitoh The Chemical Studies on the Oriental Plant Drugs. 19. Some New Constituents of Licorice Root. 1. The Structure of Licoricidin. Chem. Pharm. Bull. (Japan), 16, 1932 (1968). 

Kiuchi, F., X. Chen, and Y. Tsuda Four New Phenolic Constituents from Licorice (Root of Glycyrrhiza sp.). Heterocycles, 31, 629 (1990). 

Hatano, T., H. Kagawa, T. Yasuhara, and T. Okuda Two New Flavonoids and Other Constituents in Licorice Root Their Relative Astringency and Radical Scavenging Effects. Chem. Pharm. Bull. (Japan), 36, 2090 (1988). 

Tamir S, Eizenberg M, Somjen D, Izrael S, Vaya J (2001) Estrogen-like activity of glabrene and other constituents isolated from licorice root. J Steroid Biochem Mol Biol... 

Licorice, the root and rhizome of different varieties of Glycyrrhiza glabra (Leguminosae), has been extensively used in medicine for its antiulcer activity. The principal constituent of licorice is glycyr-rhizinic acid, a triterpenoid saponin. This chemical class is known to offer protection against ulcers. 

This review article covers constituents of licorice Glycyrrhiza species) reported up to the end of 1996. After submitting the review, the isolations of nine new phenols (336-344) from hairy root cultures of G. glabra or roots of G. uralensis were reported [478, 479]. The structures are added in Table 13 along with known compounds in the reports. 

Kitagawa, L, K. Hori, T. Taniyama, J.-L. Zhou, and M. Yoshikawa Saponin and Sapogenol. 47. On the Constituents of the Roots of Glycyrrhiza uralensis Fischer from Northeastern China. 1. Licorice-Saponins A3, B2, and C2. Chem. Pharm. Bull. (Japan), 41, 43 (1993). 

As ADA, Y., W. Li, and T. Yoshikawa Constituents of Hairy Root Cultures of Licorice. 117th Annual Meeting of Pharmaceutical Society of Japan, Abstract Papers, part 2, p. 117. Tokyo, March 1997. 

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