Lichen acids salazinic acid

Verma N, Behera BC, Sharma BO (2012a) Glucosidase inhibitory and radical scavenging properties of lichen metabolites salazinic acid, sekikaic acid and usnic acid. Hacettepe J Biol Chem 40 7-21... 

Norstictic acid, physodic acid, evemic acid, usnic acid, salazinic acid, fumar-protocetraric acid, protocetraric acid, atranorin and zeorin isolated from different lichen species are relatively strong antioxidant, antimicrobial and anticancer agents (Kosanic et al. 2010, 2013, 2014 Manojlovic et al. 2012 Rankovic et al. 2014). 

Candan M, Yilmaz M, Tay T et al (2007) Antimicrobial activity of extracts of the lichen Parmelia sulcata and its salazinic acid cmistitiient. Z NaturfOTSch 62 619-621 Cox DD (2003) A naturalist s guide to finest plants an ecology fin Eastern North America. Syracuse University Press, Syracuse, NY... 

Depsides, tridepsides, and tetradepsides consist of two, three, and four hydroxybenzoic acid residues linked by ester groups. These are the most numerous classes of secondary metabolites in lichens. More than one hundred Uchen compounds are depsidones, which have an additional ether bond between aromatic rings. Depsidones in Uchen are believed to arise by oxidative cycUzation of depsides. It has been found that depsidone and depside compounds such as atranorin, divaricatic acid, lecanoric acid, evemic acid, salazinic acid, physodic acid, and stictic acid possess important antimicrobial activity (Manojlovic et al. 2012 Kosanic et al. 2013, 2014a Rankovic et al. 2014). 

Manojlovic et al. (2012) investigated antioxidant activities for protocetraric and usnic acids from Parmelia caperata lichen and depsidone salazinic acid from... 

Komiya, T., and Shibata, S. (1969). Formation of lichen substances by mycobionts of lichens. Isolation of ( + ) usnic acid and salazinic acid from mycobionts of/ ama/i/fa spp. Chem. Pharm. Bull. 17, 1305. 

Chapter 4.5.7. Depsidones. The depsidones chalybaeizanic acid and quaesitic acid have been isolated from the lichens Xanthoparmelia amphixanthoides and Hypotrachyna quaesita respectively (Elix JA, Wardlaw JH (1999) The structure of Chalybaeizanic Acid and Quaesitic Acid, Two New Lichen Depsidones Related to Salazinic Acid. Aust J Chem 52 713). 

Allergenic Activity. Numerous lichen substances like atranorin, barbatic, diffractaic, evernic, fumarprotocetraric, lobaric, per-latolic, physodic, physodalic, protolichesterinic, salazinic, stictic and usnic acids are allergenes (Brasch and Jacobsen 1991). 

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