Library annotation

Savchuk NP, Balakin KV, Tkachenko SE. Exploring the chemogenomic knowledge space with annotated chemical libraries. Curr Opin Chem Biol 2004 8 412-17. 

Root DE, Flaherty SP, Kelley BP, Stockwell BR. Biological mechanism profiling using an annotated compound library. Chem Biol 2003 10 881-92. 

Cases M, Garcia-Serna R, Hettne K, Weeber M, van der Lei J, Boyer S, Mestres J. Chemical and biological profiling of an annotated compound library directed to the nuclear receptor family. Curr Top Med Chem 2005 5 763-72. 

This epilogue to the true book of Synesius is included in Basil Valentine His Triumphant Chariot of Antimony, with annotations of Theodore Kirkringius. M.D. With The True Book of the Learned Synesius a Greek Abbot taken out of the Emperour s Library, concerning the Philosopher s Stone. London, 1678"... 

Vaughan, Thomas.The works of Thomas Vaughan Eugenius Philalethes edited, annotated and introduced by Arthur Edward Waite. Edited by Arthur Edward Waite. London Theosophical Publ House, 1919 reprint, Chicago (IL) Library Resources, Inc, 1970. 1 microfiche... 

Valentine, Basil. Basil Valentine his Triumphant chariot of antimony, with annotations of Theodore Kirkringius, M.D. with the true book of the learned Synesius, a Greek abbot, taken out of the Emperour s library, concerning the philosopher s stone. 1678 reprint, Ann Arbor (MI) University Microfilms, 1969. 1 reel... 

Duveen, Denis I. Bibliotheca alchemica et chemica an annotated catalogue of printed books on alchemy, chemistry, and cognate subjects in the library of Denis I. Duveen. To which is added Catalogue 62, H.P. Kraus, the Duveen collection of alchemy chemistry supplementing the Bibliotheca alchemica and chemica the Duveen collection of balneology. Facsimile edition ed. Ultrecht (Utrecht ) HES, 1986. iii, 669, 98 p. ISBN 9061941768... 

Duveen, Denis I. Bibliotheca alchemica et chemica an annotated catalogue of printed books on alchemy, chemistry and cognate subjects in the library of Denis I. Duveen. London E. Weil, 1949. vii, 669p. 

McPherson, David. Ben Jonson s library and marginalia an annotated catalogue. 

Vol. 2 An annotated bibliography of the sixteenth-century books relating to the sciences in the Library of the University of Aberdeen... 

R. Craig, et al., Using Annotated Peptide Mass Spectrum Libraries for Protein Identification. J. Proteome Res., 5, no. 8 (2006) 1843-1849. 

Probes can be antibodies, other binding proteins constructed from protein fusions, or even oligonucleotide aptamers. While completion of the Human Genome Project has enabled access to content for nuclide acid arrays, the content for protein arrays is largely based upon available antibody libraries. Thus, the commercialization of protein microarrays remains largely dependent upon both commercial and institutional providers of protein content. These providers must also permit access to the data-based protein annotations. These are necessary in order for the protein array to be useful as a bioinformatics tool. 

Molecular Information Systems and Annotated Compound Libraries... 

Under this framework. Fig. 6 shows the basic pieces for constructing annotated chemical libraries. On the one hand, proteins should be stored using the appropriate annotation under their respective protein-family classification schemes (in this case, nuclear receptors). On the other hand, molecules should be stored using a unique hierarchical identifier. The link between the two entities (molecules and proteins) would be defined by pharmacological data (activity). The use of a certain criteria would then allow to construct a binary annotation matrix, from which the mapping of the chemogenomic space is established. 

The adoption of hierarchical classification schemes for both chemical and biological entities makes the storage and analysis of annotated chemical libraries computationally tractable and reduced to managing binary annotation matrices. These binary matrices are often visually illustrated as heatmaps (Fig. 7), where red indicates that the molecule is annotated to a target (i.e. shows biological activity under a certain criteria), while green... 

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