LIAD-ESI

Chapter 6, titled Selection of Ionization Methods of Analytes in the TLC-MS Techniques provides an overview of mass spectrometric techniques that can be coupled with TLC and act as specific detectors in this hyphenated approach. The mass spectrometric techniques discussed in this chapter are secondary mass spectrometry (SIMS), liquid secondary ion mass spectrometry (LSIMS), fast atom bombardment (FAB), matrix-assisted laser desorption/ionization (MALDI), atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI), electrospray ionization (ESI), desorption electrospray ionization (DESI), electrospry-assisted laser desorption/ionization (ELDI), easy ambient sonic spray ionization (EASI), direct analysis in real time (DART), laser-induced acoustic desorption/electrospray ionization (LIAD/ESI), plasma-assisted multiwavelength laser desorption/ionization (PAMLDI), atmospheric-pressure chemical ionization (APCI), and dielectric barrier discharge ionization (DBDI). For the sake of illustration, the authors introduce practical examples of implementing TLC separations with detection carried out by means of individual mass spectrometric techniques for the systematically arranged compounds belonging to different chemical classes. [Pg.9]

Similarly to dye standards, drug standards (3,4-methylenedioxy-Af-methylamphetamine, lysergic acid diethylamide, flunitrazepam) were resolved on a normal-phase TLC plate using chloroform/methanol (9 1). After drying, LIAD/ESI analysis was performed using the same procedure as for dye standards. All drugs were detected in positive-ion mode as [M+H]+ ions [54]. [Pg.97]

Laser-induced acoustic desorption electrospray ionization LIAD-ESI ESI 1.3 mm" No 31... [Pg.108]