Liability alerts

American College of Obstetricians and Gynecologists. Professional EabEity implications of AFP tests. Professional liability alert. Washington, DC American College of Obstetricians and Gynecologists, 1985. 

One of the most advanced in silico predictions of any clinical liability is based on hERG QSAR and homology models6. Structural features of hERG inhibition have been discussed and published in detail, and major structural alerts are built into knowledge-based expert systems and broadly used by chemists5. Detailed information on available QSAR efforts to predict toxic effect is discussed in details elsewhere.42-43 44... 

Information requests regarding recalls or safety alerts typically lead to analyses of a given company s or product s track record for the purpose of assessing quafity control, as well as potential legal liability or commercial vulnerability. Comparative recall data (numbers and class of severity) are also a component in industry benchmarking and trend-watching. 

When working on a specific dmg discovery project, medicinal chemists are guided by property measurements and experience to achieve a desired dmg property profile. Since not all properties can be measured during lead optimization (human PK and toxicity, for example), even compounds that fit the desired property profile often fail in the development stages. It is this uncertainty which drives our efforts to understand what stmctural features or molecular properties constitute the liabilities that might cause candidates to fail. For this reason, dmg-likeness is most commonly thought of in terms of those liabilities, and it is assessed to alert chemists about them. 

The City, all agree, was faced with a prima facie case of disparate-impact liability, ante, at 2677 The pass rate for minority candidates was half the rate for nonminority candidates, and virtually no minority candidates would have been eligible for promotion had the exam results been certified. Alerted to this stark disparity, the CSB heard expert and lay testimony, presented at public hearings, in an endeavor to ascertain whether the exams were fair and consistent with business necessity. Its investigation revealed grave cause for concern about the exam process itself and the City s failure to consider alternative selection devices. 

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