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Levocabastine

Astemi2ole (10) has further been modified into a series of 4-phenylcyclohexylamine compounds, resulting in the synthesis of cabastine, for example. Cabastine is a highly active compound and its geometric isomers are also active, demonstrating the stereoselectivity of histamine receptors toward chiral ligands. The > S, 4 R-levo antipode of cabastine was the most active, and therefore this isomer, levocabastine (13), has been chosen for further development. Because of high potency, levocabastine has been developed for topical appHcation such as eye drops and nasal spray. [Pg.139]

Topical Application. Azelastine (11) and levocabastine (13) have been developed for topical appHcation (45). The topical antihistamines address the preference of some patients for a local treatment and allow adrninistration of dmg directly to the site requited. The advantage of this therapeutic approach is likely to be in the speed of onset of symptom rehef. In contrast to earlier reports of sensitization with older antihistamines locally apphed to the skin (46), sensitization has not been reported with local appHcation to the nose or eyes. [Pg.142]

Mouse Xenopus oocyte Activation of Ca2+-dependent Cl conductance NT SR 48692 Levocabastine ... [Pg.833]

Transiently transfected COS cells Constitutive activity SR 48692 NT Levocabastine... [Pg.833]

C4H(j02 96-33-3) see Aminoglutethimide Eprosartan Glutethimide Hexobendine Levocabastine Nialamide Phenglutarimide Pioglitazone Remifentanil Vincamine acrylonitrile... [Pg.2288]

C7HJO 100-51-6) see Fluoxetine Gabapentin Ganciclovir Levocabastine Moexipril Nicotinic acid benzyl ester Perindopril Quinapril hydrochloride Ramipril Saquinavir Trandolapril benzylamine... [Pg.2304]

Cj H7N 140-29-4) see Azatadine Dicycloverine Disopyramide Ethoheptazine Isoaminile Levocabastine Mephenytoin Methylphenidate Methylphenobarbital Milnacipran hydrochloride Oxeladin Pentapiperide Pentoxyverine Pethidine Phenglutarimide Pheniramine Phenobarbital Tolazoline Triamterene Valethamate bromide 1 -benzy l-4-cyanopiperidine (C]3H 9N2 62778-37-4) see Ketanserin... [Pg.2304]

C 4H,N 1529-40-4) see Indecainide [3S-[l(cis),3a,4 3]]-l-l4-cyano-4-(4-fluorophenyl)cyclo-hexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid phenylmethyl ester (C3iH,5FN202) see Levocabastine... [Pg.2339]

C20H22N2O2S 83863-65-4) see Levocabastine 3-methyl-l-[(4-methylphenyl)sulfonyl]-4-phenyl-4-piperi-dinecarboxylic acid... [Pg.2418]

C20H23NO4S 80138-94-9) see Levocabastine tranx-3-methyl-l-[(4-methylphenyl)sulfonyll-4-phenyl-4-piperidinecarboxylic acid phenylmethyl ester (C27H29NO4S 104907-69-9) see Levocabastine ( )-JV-methyl-2-[3-(l-methyl-4-piperidinyl)-l//-indol-S-yllethenesulfonamide... [Pg.2418]

C7H7CIO2S 98-59-9) see Benproperine Brinzolamide Carzenide Cefoxitin Diazepam Flurotyl Fosinopril Gusperimus trihydrochloride Idarubicin Idoxuridine Indeloxacine Levocabastine Mazindol Medazepam Mibefradil hydrochloride Nemonapride Pioglitazone Prenalterol Ropinirole Tinidazole Tolterodine p-toluenesulfonamide... [Pg.2447]

Levocabastine H,-receptor antagonist Downregulates intracellular adhesion molecules, decreasing the inflammatory response may be used for up to 2 weeks... [Pg.940]

Levocabastine 1 drop in affected eye(s) four times daily Ocular stinging, headache... [Pg.940]

Levocabastine (Livostin) and olopatadine (Patanol) are ophthalmic antihistamines that can be used for allergic conjunctivitis that is often associated with allergic rhinitis. However, systemic antihistamines are usually effective for allergic conjunctivitis, making an ocular product unnecessary. They may be a logical addition to nasal glucocorticoids when ocular symptoms occur. [Pg.915]

Levocabastine hydrochloride Ph.Eur. Related substances Small organic compound na ... [Pg.158]

FIGURE 4 Electropherogram of levocabastine hydrochloride including several related substances. (Reprinted with permission from Pharmeuropa 10(2) (1998) 245.)... [Pg.162]

See other pages where Levocabastine is mentioned: [Pg.139]    [Pg.111]    [Pg.226]    [Pg.240]    [Pg.832]    [Pg.833]    [Pg.833]    [Pg.834]    [Pg.1160]    [Pg.1160]    [Pg.1161]    [Pg.2305]    [Pg.2328]    [Pg.2339]    [Pg.2339]    [Pg.2380]    [Pg.2387]    [Pg.2387]    [Pg.2395]    [Pg.2420]    [Pg.591]    [Pg.608]    [Pg.593]    [Pg.610]    [Pg.617]    [Pg.36]    [Pg.37]    [Pg.157]    [Pg.160]    [Pg.250]   
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See also in sourсe #XX -- [ Pg.409 , Pg.1108 ]

See also in sourсe #XX -- [ Pg.204 ]

See also in sourсe #XX -- [ Pg.8 , Pg.231 , Pg.254 , Pg.401 , Pg.407 , Pg.624 ]



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