Quinapril hydrochloride

C7HJO 100-51-6) see Fluoxetine Gabapentin Ganciclovir Levocabastine Moexipril Nicotinic acid benzyl ester Perindopril Quinapril hydrochloride Ramipril Saquinavir Trandolapril benzylamine... 

C23H30O7 133991-63-6) see Loteprednol etabonate (3p,16p,17a,18p,20a)-18-[[3-I4-t(ethoxycarbonyl)oxy]-3-methoxyphenyl)-l-oxo-2-propenyl]oxy]-ll,17-dimeth-oxyyohimban-16-carboxylic acid methyl ester (C3ftH42N20(o 49806-34-0) see Rescimetol AT-(l-ethoxycarbonyI-3-phenylpropyl)-L-alanine (C,, H 3N04) see Quinapril hydrochloride A7-[l(5)-ethoxycarbonyl-3-phenylpropyl]-L-alanine (C,gH2 N04 82717-962) see Imidapril Moexipril Quinapril hydrochloride Spirapril Trandolapril A -[l(5)-ethoxycarbonyl-3-phenylpropyl]-L-aIanine benzo-thiazol-2-yIthio ester... 

C,yH2i>N04) see Quinapril hydrochloride /V-(l(5)-ethoxycarbonyl-3-phenyipropyl]-L-alaninerer/-butyl ester... 

C HiiNOj 63-91-2) see Melphalan Quinapril hydrochloride Saquinavir L-phenylalanine fert-hutyl ester hydrochloride (CijHtoCINOj 15100-75-1) see Alacepril D-phenylalanine methyl ester (CioHijNOj 21685-51-8) see Nateglinide L-phenylalanine methyl ester hydrochloride (C10H14CINO2 7524-50-7) see Angiolensinatnide... 

A recent patent application describes, in part, a multikilogram scale synthesis of quinapril (Jennings, 2004). The carboxyanhydride of 26 is prepared by treatment with phosgene (Scheme 10.8) (Youssefyeh et al., 1987). This is next coupled with tetrahydroisoquinoline subunit 27 in the presence of catalytic acid. Without isolation of the resultant quinapril t-butyl ester, the reaction solution is treated with acetic acid and anhydrous hydrogen chloride to deprotect the ester. Amorphous quinapril hydrochloride is obtained via treatment with acetonitrile. 

Guo Y, Byrn SR, Zografi G. Effects of lyophilization on the physical characteristics and chemical stability of amorphous quinapril hydrochloride. Pharm Res 2000 17 930-935. 

Guo Y, Byrn S, Zografi G. Physical characteristics and chemical degradation of amorphous quinapril hydrochloride. J Pharm Sci 2000 89(1) 128 143. 

Ci. jH2iN04 82586-59-2) see Moexipril benzyl (.S)-l,2,3,4-tetrahydro-3-isoquinolinccarboxylate (C 711I7N02 77497-96-2) see Quinapril hydrochloride 1-(1-benzyl-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimida/.o-linonc... 

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