Leukocytes homologue

Boisvert WA, Santiago R, Curtiss LK, Terkeltaub RA. A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest 1998 101(2) 353-363. 

Of particular note, fish immunologists generally lack some reagents to quantify leukocyte subsets, yet this area of research is improving as genomics and proteomics (mostly from zebrafish) are finding homologues of many cell surface markers. Almost... 

Coronin 1 (coronin lA) is exclusively expressed in mammalian leukocytes, with no detectable expression in any other cell type ( and data not shown). Several other coronin isoforms are expressed as well in leukocytes and therefore coronin 1 may have evolved to perform a highly specialized function in leukocytes. Interestingly, of all mammalian coronin isoforms, coronin 1 is the closest homologue to Dictyostelium short coronin. Whether or not the other coronin isoforms have evolved from coronin 1 or have arisen through a different evolutionary path is discussed to in Chapter 4. 

CXCL8/IL-8, and its murine homologue CXCLl/GRO-a, were initially characterized as neutrophil chemoattractants and as such have been shown to play an important role in neutrophil-mediated acute inflammation (Harada et al., 1994). However, it is now known to have much more wide-ranging effects on both non-leukocyte and leukocyte subtypes of cells (Harada et al., 1994). The CXCL8/CXCL1 receptor, CXCR2, is also expressed on the surface of monocytes (Moser et al., 1993 Chuntharapai et al.. 

Martin et al. 2001). Mouse vanin-3 expression is widely found in normal mouse tissue such as spleen, peripheral blood leukocyte, liver, kidney, thymus and heart. Mouse vanin-3 expression is induced by oxidative stress, which is involved in antioxidant response elements as well as mouse vanin-1 gene (Berruyer et al. 2004). The cell lysate showed a pantetheine-hydrolysing activity (Martin et al. 2001) as well as mouse vanin-1 when the enzymatic activity was measured using the lysates of the cells transfected with mouse vanin-3 cDNA. On the other hand, VNN3, a putative human gene homologue of mouse Vanin-3, seems to encode an incomplete protein (Nitto et al. 2008). 

Baranger, K., Zani, M.L., Labas, V., et al. (2011) Secretory leukocyte protease inhibitor (SLPI) is, hke its homologue tr pin-2 (pre-elafin), a transglutaminase substrate. PLoS One 6, e20976. 

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