Calcium leucovorin

Leucovorin Calcium (Folinic Acid Citrovorum Factor)... [Pg.64]

Leucovorin calcium Wellcovorin) Folic acid antagonists (eg, methotrexate)... [Pg.371]

Toxic effects Toxic effects, potentially serious, may be related in frequency and severity to dose or frequency of administration, but have been seen at all doses. These effects can occur at any time during therapy follow patients closely. Most adverse reactions are reversible if detected early. When reactions occur, reduce dosage or discontinue drug and take appropriate corrective measures this could include use of leucovorin calcium. Use caution if therapy is reinstituted. [Pg.1973]

It is used as leucovorin calcium (calcium folinate). It is 5-formyl derivative of tetrahydrofolic acid and it acts as an antidote to folic acid antagonists like methotrexate or pyrimethamine which inhibit the enzyme dihydrofolate reductase. [Pg.397]

Common Name Calcio folinato Calcium folinate Leucovorin calcium Structural Formula ... [Pg.2024]

Leucovorin calcium Leucovorin calcium Wellcovorin Wellcovorin... [Pg.2024]

Reduced folates are co-factors for the 5-fluorodeoxy-uridine monophosphate-thymidilate synthetase reaction. Leucovorin (calcium fohnate) therefore potentiates the toxicity of 5-fluorouracil, and fatal adverse effects have been reported in patients over 65 years of age receiving high-dose treatment with leucovorin simultaneously with fluorouracil. This has led some groups to recommend that initial dose levels of fluorouracil should be lowered by 20% and that therapy be stopped temporarily at the first sign of distal gastrointestinal adverse effects (SEDA-15, 414). [Pg.1435]

Leucovorin Caldum, U5P. Leucovorin calcium, A/(4- [(2-amino-5-formyll,4.5,6,7,8-hexahydro-4-oxo-6-pteri-dinyI)methyl]amino]benzoyl]-L-glutamic acid, calcium salt, calcium 5-formyl-5,6.7,8-tetrahydrofolate, calcium folinate, occurs as a yellowish-white or yellow, odorless, microcrystalline powder that is insoluble in alcohol and very soluble in water. [Pg.897]

Leucovorin folinicadd. leucovorin calcium calcium folinate. leukaemomycin C daunorubidn. [Pg.162]

Trade names Antrex FUSILEV (Spectrum pharmaceuticals) Leucovorin calcium... [Pg.338]

McGuire BW et al. Absorption kinetics of orally administered leucovorin calcium. NCI Monographs, 1987, 5 47-56. [Pg.436]

McGuire BW et al. Pharmacokinetics of leucovorin calcium after intravenous, intramuscular, and oral administration. Clinical Pharmacy, 1988, 7 52-58. [Pg.436]

LEUCOVORIN CALCIUM (FOLINIC ACID) (Wellcovorin tablets 5 mg)... [Pg.384]

Leucovorin calcium is a folic acid derivative, which acts as an antidote to dmgs that antagonize foUc add, such as methotrexate. Oral and parenteral used in treatment to diminish toxidty and counterad effed of overdosage of foUc acid antagonists. Parenteral used in treatment of megaloblastic anania caused by folic acid defidency when oral therapy is not feasible. [Pg.384]

A. Parenteral. Leucovorin calcium (Wellcovorin, others), 3- and 10-mg/mL vials 50, 100, and 350 mg for reconstitution (use sterile water rather than diluent provided, which contains benzyl alcohol). [Pg.461]

See also in sourсe #XX -- [ Pg.8 ]

See also in sourсe #XX -- [ Pg.8 , Pg.315 ]

See also in sourсe #XX -- [ Pg.681 ]

See also in sourсe #XX -- [ Pg.8 , Pg.315 ]

See also in sourсe #XX -- [ Pg.8 , Pg.315 ]

See also in sourсe #XX -- [ Pg.8 , Pg.315 ]

See also in sourсe #XX -- [ Pg.927 ]

See also in sourсe #XX -- [ Pg.8 , Pg.315 ]

See also in sourсe #XX -- [ Pg.8 , Pg.315 ]

See also in sourсe #XX -- [ Pg.8 , Pg.315 ]

See also in sourсe #XX -- [ Pg.384 ]

See also in sourсe #XX -- [ Pg.460 ]

See also in sourсe #XX -- [ Pg.8 , Pg.315 ]

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