Leptin receptors modulation

Modulation of Leptin Receptor Expression in the Cardiovascular System... 

Shigemura N, Miura H, Kusakabe Y, Hino A, Ninomiya Y (2003) Expression of leptin receptor (Ob-R) isoforms and signal transducers and activators of transcription (STATs) mRNAs in the mouse taste buds. Arch Histol Cytol 66 253-260 Shigemura N, Ohta R, Kusakabe Y, Miura H, Hino A, Koyano K, Nakashima K, Ninomiya Y (2004) Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology 145 839-847... 

Dixit VD, Schaffer EM, Pyle RS, CoUins GD, Sakthivel SK, Palaniappan R, I.illaid JW, Taub DD (2004) Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J CUn Invest 114 57-66 Dmitrieva N, Shelton D, Rice ASC, McMahon SB (1997) The role of nerve growth factor in a model of visceral inflammation. Neuroscience 78 449-459 Doak GJ, Sawynok J (1997) Formalin-induced nodceptive behavior and edema involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes. Neuroscience 80 939-949 Dobner PR (2006) Neurotensin and pain modulation. Peptides 27 2405-2414 Dobolyi A, Ueda H, Uchida H, Palkovits M, Usdin TB (2002) Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. Proc Natl Acad Sci U S A 99 1651-1656... 

Macrophages/DCs and lymphocytes express a variety of adrenergic receptors. Increased concenh ations of NE or dopamine can modulate T cells polarization toward Th2 profile, stimulate IL-4, IL-5, and IL-13 secretion (Kohm and Sanders, 2001). The same Th2 polarization can be induced by histamine, serotonin, neuropeptides such as substance P, vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide, calcitonin gene-related peptide, a-melanocyte-stimulating hormone, and leptin (Steinman, 2004). 

Kawai K, Sugimoto K, Nakashima K, Miura H, Ninomiya Y (2000) Leptin as a modulator of sweet taste sensitivities in mice. Proc Natl Acad Sci USA 97 11044-11049 Kim MR, Kusakabe Y, Miura H, Shindo Y, Ninomiya Y, Hino A (2003) Regional expression patterns of taste receptors and gustducin in the mouse tongue. Biochem Biophys Res Commun 312 500-506... 

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