Lectin families

Fig. 19. The sulfated glycoprotein mimics were tested for biological activity against the se-lectin family of proteins, which are involved in the inflammatory response. These results suggest that length may be a factor in the selectivity of polymers for different proteins...

The interesting chemistry of sialic acid has been discussed in several reviews [213,214,215]. Sialic acid is an important component of complex oligosaccharides, when it is placed in the terminal position, and often masks the penultimate saccharide sequences. In this position, it interacts with numerous receptors including the influenza virus neuraminidase, and receptors mediating intercellular interactions such as the selectins (members of the C-t) e animal lectin family) and siglecs (or sialoadhesins, members of the immunoglobulin superfamily). The structure of influenza B neuraminidase in complex with sialic acid has been solved by X-ray crystallography at 2.2 A resolution (O Fig. 17) [216]. 

The number of identical or different subunits which oligomerize to constitute a biologically relevant receptor is considered in detail. Additionally, we present the sometimes well-documented but often speculative biological roles for the members of these lectin families. 

There is a field in chemistry that remains completely open to research and the interactions established between anthocyanins and the large bioorganic and inorganic molecules. Good representatives would be proteins for instance, members of the lectin family and also the human insulin with its 51 amino acids. 

Glenn, KA Nelson, RF Wen, HM Mallinger, AJ Paulson, HL. Diversity in Tissue Expression, Substrate Binding, and SCF Complex Formation for a Lectin Family of Ubiquitin Ligases. JBiol Chew., 2008, 283(19), 12717-29. 

IgE receptors bind either to the Fc portion of the immunoglobulin, and thus belong to the Fc receptor superfamily, or to carbohydrate moieties. The high-affinity receptor (FceRI) and the low-affinity receptor (FceRII/CD23) fall in the first group, while, Mac2/galectin-3, a member of the S-type lectin family, falls in the second one. 

---