Lean skeletal muscle tissue

Muscle is the major site of glucose disposal in man, and approximately 80% of total body glucose uptake occurs in skeletal muscle. In response to a physiologic increase in plasma insulin concentration, muscle glucose uptake increases linearly, reaching a plateau value of 10 mg/kg per minute. In contrast, in lean type 2 diabetic subjects, the onset of insulin action is delayed for 40 minutes, and the ability of insulin to stimulate leg glucose uptake is reduced by 50%. Therefore the primary site of insulin resistance in type 2 diabetic subjects resides in muscle tissue. 

---