Lead, terphenyl derivatives

C23H26O6, Mr 422.46, prismatic cryst., mp. 156 C. p-Terphenyl derivative from cultures of Aspergillus candidus. T. in vitro inhibits the formation of immunoglobulin E in human lymphocytes (IC50 0.18 nM). It is investigated as lead structure for the synthesis of therapeutics against asthma, atopic dermatitis and other allergic diseases. 

Hino S, Ohnstead M, Phillips AD, Wright RJ, Power PP (2004) Terphenyl ligand stabilized lead(II) derivatives steric effects and lead-lead bonding in diplumbenes. Inorg Chem... 

The 2 -formyl derivative 57 was further subjected to functional group interconversions, leading to a series of a new 2 -substituted m-terphenyls. Wittig reaction on 57 provided the alkenyl derivative 61 in 58% yield [21], The oxime 62 was obtained in 62% yield by treatment with hydroxylamine hydrochloride. 

The use of monomers having additional p-phenylene rings, i.e. terphenyl or quaterphenyl derived, leads to polymers with increased rigidity and increased degree of crystallinity. TTius, terphenyl diol (11) was condensed with a number of dihalobenzenoid compounds. ... 

Degradation is determined by noting the disappearance of the characteristic peaks of the parent material in GC or MS analysis, and by the appearance of peaks indicating products the products are not always identified. Reaction pathways include direct dechlorination, and, in the presence of oxygen containing solvents, the formation of substituted hydroxy derivatives these are illustrated in Fig. 2. They may be accompanied by, or followed by, isomerisation and condensation, leading to the production of terphenyls, tetraphenyls, and dibenzofurans (Fig. 2). 

---