Aspergillus candidus

A novel fungal metabolite, hydroxyterphenyllin (242) from Aspergillus candidus found in unbleached flour was shown to be an active inhibiting ingredient when tested in wheat coleoptile bioassays at 10 3 - 10-5M. Terphenyllin (244, 245) was also identified from the same source but was less active (at 10 % ). ... 

Chlorflavonin (166) was discovered in the culture broth of Aspergillus candidus [199-201]. A biosynthetic study of this fungal metabolite indicates that it is a true metabolite and is synthesized de novo by this microbe [202]. It was also detected in Aspergillus candidus and A. campestris [203]. The fungus Monilinia fructicola produces chloromonilinic acids A (167) and B (168) derived from chloromonilicin [204], to be discussed later. 

Aspergillus candidus is a cream colored mold whose colonization of the grain results In a sharp escalation of the spawn temperature. 

C23H26O6, Mr 422.46, prismatic cryst., mp. 156 C. p-Terphenyl derivative from cultures of Aspergillus candidus. T. in vitro inhibits the formation of immunoglobulin E in human lymphocytes (IC50 0.18 nM). It is investigated as lead structure for the synthesis of therapeutics against asthma, atopic dermatitis and other allergic diseases. 

More than 200 flavonoids are known today. Most are formed in higher plants (including mosses and ferns). Only a few are synthesized in microorganisms, e.g., Aspergillus candidus. Animals are unable to form flavonoids. The flavonoids present, for instance, in the wings of butterflies are derived from compounds ingested with the diet. 

Zhang P, Zhou PP, Yu LJ (2009) An endophytic taxol-producing fungus from Taxus xmedia, Aspergillus candidus MD3. FEMS Microbiol Lett 293 155-159. doi 10.1111/ j.l574-6968.2009.01481.x... 

The biosynthesis of citrinin (XXXIX) was independently investigated with radioactive tracers by Birch et al. (1958c) utilizing Aspergillus candidus] and by ScHWENK and collaborators (1958) with labelled acetate and methionine-methyl-in Penicillium citrinum cultures. It was unequivocally demonstrated that this compound arises by cyclization of a poly j8-ketide made of 5 acetyl units, and that its two extra methyls and the carboxyl function arise from the Ci-pool (Fig. 16). It has subsequently been suggested (Hassall and Jones, 1962) that (XL) and 3>4-dihydro-6,8-dihydroxy-3,4,5"trimethylisocoumarin-carboxylic acid (XLI) are precursors to citrinin. This postulation followed the finings cf. Hassall, 1965) that one mutant strain of A, terreus produced only (XLI),... 

Incorporation of C-and C-labelled precursors into chloroflavonin (119) by cultures of Aspergillus candidus revealed... 

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