Lead chemistry

Aqueous solubility, potency and permeability are three factors under medicinal chemistry control that must be optimized to achieve a compound with acceptable oral absorption. Typically, a lead (chemistry starting point) is deficient in all three parameters. The inter-relationships of these three parameters has been described in a series of publications from Pfizer researchers [7, 8]. Figure 9.1 depicts graphically the minimum acceptable solubility as a function of projected clinical potency and intestinal permeability. A minimum thermodynamic aqueous solubility of 52... 

H. Sakurai and A. Sekiguchi, in Frontiers of Organogermanium, -Jin, and -Lead Chemistry (Eds. E. Lukevics and L. Ignatovich), Latvian Inst, of Organic Synthesis, Riga, 1993, p.102 A. Sekiguchi, T. Yatabe, H. Naito, C. Kabuto and H. Sakurai, Chem. Lett., 1697 (1992). 

Part V, Lead Chemistry, ILZRO Res. Dig. No. 13, International Lead Zinc Research Organization, Inc., New York, 1967... 

Jutzi, P. In Frontiers of Organogermanium, -Tin and -Lead Chemistry Lukovics, E., Ignatovich, L., Eds. Latvian Instutite of Organic Synthesis Riga, 1993 pp 147-158. 

Michne, W.F. Hit-to-lead chemistry a key element in new lead generation. Pharm. News 1996, 3, 19—21. 

New Leads Chemistry Initiative 340 Kingsland Street Nudey, NJ 07110 USA... 

Lead-207 NMR will never be such an important spectroscopic tool like tin-119 NMR however, it is very useful for the solution of many new and old problems in lead chemistry and will attract the interest of both the preparative as well as analytical chemist in the years to come. 

Since plumbylene is a stable state in lead chemistry, oxidative addition of organo-metallics to plumbylene is an attractive way to lead-centered anions. Following this route, multidecker anions can be prepared for lead, if crown or cryptand ligands coordinate the alkali metal cations (equation 62)70. 

In lead chemistry, the level of metallation was temperature-dependent (equation 97)3c. 

In lead chemistry, the reaction between the trimesitylplumbyllithium and acyl chlorides led to acylplumbanes in high yield and to the first isolable acylplumbane as a yellow crystalline compound, whose structure was confirmed by single crystal X-ray analysis... 

J) Anonymous ILZRO Research Digest No. 22, Part V, Lead Chemistry, Autumn, 1968, Intern. Lead Zinc Res. Organ., New York, New York. 

Dr. Jennifer A. Van camp Hit to Lead Chemistry Global Pharmaceutical R D Abbott Laboratories 200 Abbott Park Rd. 

Casas, J., Sordo, J. (2006). Lead Chemistry, Analytical Aspects, Environmental Impact, and Health Effects. Amsterdam Elsevier Science. Chapter 1 deals with the history, occurrence, properties, and uses of lead compounds. Chapters 2 and 3 cover the chemistry of coordination and organolead compounds. 

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