LBD, Ligand-binding domain

LBD, ligand binding domain). In the linear schematic at the top, the general functions of the respective regions of NRs are noted. 

SHRs are built in a modular structure with similar structure elements. They contain a DNA-binding domain (DBD), a hinge region with a nuclear location signal (NLS), a ligand-binding domain (LBD) and several transcriptional activation functions (Fig. 1). 

Members of the different SERM families bind to the ligand-binding domain (LBD) of the ER, whose particular crystal structure has been revealed for estradiol and for raloxifene (Brzozowski et al. 1997). Once inserted into the binding cavity, estradiol makes direct hydrogen bonds bewteen its A-ring and... 

Lewis, D.F.V. et al. (2002) Molecular modelling of the human glucocorticoid receptor (hGR) ligand-binding domain (LBD) by homology with the human estrogen receptor a (hERa) LBD quantitative structure-activity... 

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