Latanoprost side effects

Schmidtborn F. Systemische Nebenwirkung von Latanoprost bei einem Kind mit Aniridie und Glaukom. [Systemic side-effects of latanoprost in a child with aniridia and glaucoma.] Ophthalmologe 1998 95(9) 633-4. 

Figure 10-2 Left eye of patient treated with latanoprost before (A) and after (B) (> months of treatment. (Adapted from Aim A, Stjernschantz J. Effects on intraocular pressure and side effects of 0.005% latanoprost applied once daily, evening or morning. A comparison with timolol. Ophthalmology 1995 102 1743-1752.)...

Latanoprost appears to be devoid of any systemic side effects. In contrast to [3-blockers, latanoprost has no significant effects on the cardiovascular system or pulmonary system. 

Safety assessments in travoprost studies have included evaluation of visual acuity, pupil diameter, iris color, anterior chamber flare, conjunctival hyperemia, pulse, blood pressure, blood chemistry profiles, and urinalysis values. The observed adverse events have generally been mild to moderate and have resolved without treatment. Most of the side effects seen with latanoprost can occur with travoprost treatment. Conjunctival hyperemia induced by travoprost is clinically insignificant but generally more than that observed with latanoprost. 

Gonjunctival hyperemia is the most frequent side effect associated with bimatoprost therapy and generally occurs more often than in patients treated with travoprost or latanoprost. Most occurrences, however, are mild. For most patients the hyperemia occurs within 6 weeks of initiating treatment. However, hyperemia can be seen as early as within 24 hours for some patients. The severity of hyperemia often diminishes over time and is not associated with ocular surface or intraocular inflammation. The only other frequent side effect (reported in more than 10% of patients) is eye pruritus. 

E Due to her concomitant disease states, AK should avoid beta-blockers, adrenergic agents, and sulfa medications. Pilocarpine is not a good choice for AK due to its bothersome local side effects. Latanoprost is a good initial choice for AK due to its convenient once daily dosing and mild local and systemic side effects. 

Latanoprost Latanoprost (Xalatan) is available as a 0.005% sterile ophthalmic solution in a 2.S-mL dispenser bottle. Latanoprost is also marketed as a combination ophthalmic product with the /3-adrenergic blocking agent timolol, which apparently enhances lOP-lowering by decreasing the production of aqueous humor. Cautions and side effects are similar to those for other ophthalmic prostanoids. 

In long-term clinical use, prostanoids are known to cause iris pigmentation as a characteristic side-effect this has been observed in 5-15% of patients treated [27], In cultured melanoma cells, a carboxylic acid of latanoprost has been reported to increase melanogenesis [45], However, a carboxylic acid of tafluprost did not have the stimulatory effects... 

Sensory systems A case series of three patients who presented with periocular changes in the treated eye following chronic administration of unilateral latanoprost 0.005% has appeared published [53 ]. The clinical changes included worsening of dermatochalasis, deepening of superior sulcus and hollowness of the lid. This similar observation was previously described in usage of bimatoprost 0.03% and travoprost 0.004%. However this has not been reported in latanoprost instillation. Therefore, patients should be made aware of these potential side effects. 

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