Lamellar ichthyosis treatment

Ganemo, A., Virtanen, M., and Vahlquist, A., Improved topical treatment of lamellar ichthyosis a double-blind study of four different cream mixtures, Br. J. Dermatol., 141, 1027, 1999. 

Stege, H., Hofmann, B., Ruzicka, T., and Lehmann, P, Topical application of tazarotene in the treatment of nonerythrodermic lamellar ichthyosis, Arch. Dermatol., 134, 640, 1998. 

Kiistala, R., Lauharanta, J., and Kanerva, L., Transepidermal water loss and sweat gland response in lamellar ichthyosis before and during treatment with etretinate report of three cases, Acta Derm. 

Peck, G.L. and Yoder, F.W. (1976) Treatment of lamellar ichthyosis and other keratinising dermatoses with an oral synthetic retinoid. Lancet, 2, 1172-1174. 

Fig. 5. Generalized lamellar ichthyosis prior to treatment with isotretinoin. [Reprinted with permission from Peck and Yoder (1976).]...

The sequence of histologic and clinical changes in lamellar ichthyosis suggests that the effect of these compounds on the skin are mediated by means of their influence at the level of the underlying epidermis insofar as after several days of topical treatment a normal skin surface abruptly appears clinically, consequent to sheet-like desquamation of the entire thickened stratum corneum. This is correlated histologically with the emergence of a normally thin stratum corneum and reduction in thickness of the epidermis. No clinical... 

Figure 23.1 Lamellar ichthyosis, lateral thigh, prior to treatment...

Yoder, F. W. and Peck, G. L. (1977). Treatment of lamellar ichthyosis, Darier s disease, and pityriasis rubra pilaris with oral 13-cis retinoic acid. Clin. Res. 25,288A... 

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