Pityriasis rubra pilaris

Acitretine ch3o x x Oral 0.25-1.0 mg/kg/d Psoriasis (erythrodermic, pustular, and severe recalcitrant) Palmoplantar keratoderma pustulosis palmoplantaris, icthyosis, Darier s disease, pityriasis rubra pilaris, lichen ruber planus... 

Propylene glycol is used under polyethylene occlusion or with 6% salicylic acid for the treatment of ichthyosis, palmar and plantar keratodermas, psoriasis, pityriasis rubra pilaris, keratosis pilaris, and hypertrophic lichen planus. 

Gokal R+, BMJ 1,721 (1979) Rees PJ, BMJ I, 955 Papulo-nodular lesions (1992) Shelley WB +, Cutis 50, 87 (observation) Photosensitivity Pityriasis rubra pilaris Pruritus (I-5%)... 

Lichenoid eruption Lupus erythematosus Pityriasis rubra pilaris Pruritus (1-5%)... 

P9. Porter, D., and Shuster, S., Epidermal renewal and amino acids in psoriasis and pityriasis rubra pilaris. Arch. Dermatol. 98, 339-343 (1968). 

These accomplishments represent the culmination of a decade of clinical and laboratory investigation into the therapeutic spectrum and the mechanisms of action of retinoids in the skin. This interest arose from the use of oral vitamin A as therapy for a variety of dermatoses for the past 40 years. This usage was based initially on the similarity between the follicular keratoses seen in vitamin A deficiency and those in previously treatment-resistant skin disorders, such as Darier s disease (keratosis follicularis) and pityriasis rubra pilaris. Vitamin A deficiency thus provides a conceptual link in understanding how retinoids may be effective as therapy for a wide range of dermatologic disorders. 

Stalling SS, Vu JR, English JC. Telaprevir-induced pityriasis rubra pilaris-like drug eruption. Arch Dermatol 2012 148(10) 1215-7. 

The following clinical diagnoses have been considered Pityriasis rubra pilaris (PRP) keratosis pilaris generalized comedone naevus and ichthyosis with a pronounced follicular component. 

The patients with pityriasis rubra pilaris had not responded to topical retinoic acid, oral vitamin A (750 000 I.U. for 6 weeks), topical keratolytics, topical cr-hydroxy acids, or systemic methotrexate. 

Figure 23.3 Pityriasis rubra pilaris, knee, prior to treatment Table 23.2 Side effects in 54 patients...

Successful treatment of congenital ichthyosiform erythroderma, pityriasis rubra pilaris, and Darier s disease have been documented with oral all-trans retinoic acid in daily doses varying from 10 to 60 mg for several weeks to monthsOrfanos et al. used oral 13-cis retinoic acid in the treatment of psoriasis with equivocal results More recently, better results were obtained in psoriasis using a trimethylphenyl derivative of retinoic acid (RO-10/9359, Hoffman-La Roche, Basle), up to 100 mg/day, either alone or in combination with topical dithranoP". Since this derivative appears to be more effective than 13-cis retinoic acid in the treatment of psoriasis, a study comparing these two synthetic retinoids in the treatment of other disorders of keratinization should be of value. 

Yoder, F. W. and Peck, G. L. (1977). Treatment of lamellar ichthyosis, Darier s disease, and pityriasis rubra pilaris with oral 13-cis retinoic acid. Clin. Res. 25,288A... 

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