Lactose disintegration rate

FIG. 8. Initial axial disintegrating pressure rate vs. disintegration time of dicalcium phosphate and lactose tablets containing 2% super disintegrants. (O) Dicalcium phosphate r = 0.95, p < 0.05, significant correlation (A) Lactose r = 0.10, p < 0.05, no significant correlation. (Replotted from Ref. 27.)... 

In hydrochlorothiazid tablets almost all commercial types of crospovidone were compared using soluble and insoluble fillers [662]. In the case of dicalcium phosphate as filler the disintegration times and dissolution results of the active ingredient depend strongly on the type of crospovidone used. In the case of lactose as filler no significant difference between all crospovidone types could be seen in the disintegration time of the tablet and the dissolution rate of hydrochlorothiazide. 

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