Metallo-beta-lactamase

R. Nagano, Y. Adachi, H. Imamura, K. Yamada, T. Hashizume, H. Morishima, Car-bapenem Derivatives as Potential Inhibitors of Various beta-Lactamases, Including Class B Metallo-beta-Lactamases , Antimicrob. Agents Chemother. 1999, 43, 2497-2503. [Pg.244]

Yong D, Toleman MA, Giske CG et al (2009) Characterization of a new metallo-beta-lactamase gene, bla(NDM-l), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 53(12) 5046-5054... [Pg.211]

Kaminskaia, N. V., Spingler, B., Lippard, S. J., Hydrolysis of beta-lactam antibiotics catalyzed by dinuclear zinc(II) complexes Functional mimics of metallo-beta-lactamases. J. Am. Chem. Soc. 2000, 122, 6411-6422. [Pg.858]

Beta-lactamase Aeromonas spp., Steno-trophomonas maltophilia, Bacteroides fragilis NA Potentiation of beta-lactams against strains expressing a metallo-beta-lactamase [26]... [Pg.502]

Chromosomal metallo-beta-lactamases that hydrolyze carbapenem antibiotics, such as imipenem, meropenem, or biapenem, are present in some Stenotro-phomonas, Bacteroides, andAeromonas strains [26], Some clinical/5, aeruginosa and Serratia marcescens isolates have a plasmid that carries metallo-beta-lactamase genes [26], These enzymes are not inactivated by inhibitors of serine-based beta-lactamases such as clavulanic acid or sulbactam analogs. Enzyme-... [Pg.504]

K Bush. Metallo-beta-lactamases a class apart. Clin Infect Dis 27(Suppl 1) S48-S53, 1998. [Pg.511]

R Nagano, Y Adachi, H Imam lira, K Yamada, T Hashizume, H Morishima. Carba-penem derivatives as potential inhibitors of various beta-lactamases, including class B metallo-beta-lactamases. Antimicrob Agents Chemother 43 2497-2503, 1999. [Pg.512]

JH Toney, PM Fitzgerald, N Grover-Sharma, SH Olson, WJ May, JG Sundelof, DE Vanderwall, KA Cleary, SK Grant, JK Wu, JW Kozarich, DL Pompliano, GG Hammond. Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase. Chem Biol 5 185-196, 1998. [Pg.512]

GG Hammond, JL Huber, ML Greenlee, JB Laub, K Young, LL Silver, JM Balko-vec, KD Pryor, JK Wu, B Leiting, DL Pompliano, JH Toney. Inhibition of IMP-1 metallo-beta-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives. FEMS Microbiol Lett 179 289-296, 1999. [Pg.512]

Wang, J., Okamoto, Y., Morishita, J., Tsuboi, K., Miyatake, A., and Ueda, N. (2006). Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. J. Biol. Chem. 281, 12325—12335. [Pg.56]

Park H, EN Brothers, KM Merz Jr (2005) Hybrid QM/MM and DIPT investigations of the catalytic mechanism and inhibition of the dinuclear zinc metallo-beta-lactamase CcrA from Bacteroides fragilis. J. Am. Chem. Soc. 127 (12) 4232-4241... [Pg.304]

Walsh TR, Toleman MA, Poirel L, Nordmann P. Metallo-beta-lactamases the quiet before the storm Clin. Microbiol. Rev. 38. 2005 18 306-325. [Pg.100]

Bebrone, C. (2007). Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily. [Pg.246]

Sanschagrin, F., Levesque, R. C. (2005). A specific peptide inhibitor of the class B metallo-beta-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display. J. Antimicrob. Chemother., 55, 252-255. [Pg.90]

Crowder MW, Spencer J, Vila AJ (2006) Metallo-beta-lactamases novel weaponry for antibiotic resistance in bacteria. Acc Chem Res 39 721-728... [Pg.150]

Abriata LA, Gonzalez LJ, Llarrull LI, Tomatis PE, Myers WK, Costello AL, Tierney DL, Vila AJ (2008) Engineered mononuclear variants in Bacillus cereus metallo-beta-lactamase Bell are inactive. Biochemistry 47 8590-8599... [Pg.150]

Gonzalez JM, Martin FJM, Costello AL, Tierney DL, Vila AJ (2007) The zn2 position in metallo-beta-lactamases is critical for activity a study on chimeric metal sites on a conserved protein scaffold. J Mol Biol 373 1141-1156... [Pg.150]

Cornaglia G, Mazzariol A, Lauretti L, Rossoli-ni GM, Fontana R, Hospital outbreak of carba-penem-resistant Pseudomonas aeruginosa producing VIM-1, a novel transferable metallo-beta-lactamase. Clin. Infect. Dis. 2000, 31, 1119-1125. [Pg.1754]

Concha NO, Rasmussen BA, Bush K, Herzberg O Crystal structures of the cadmium- and mercury-substituted metallo-beta-lactamase from Bacteroides fragilis. Protein Sci 1997, 6(12) 2671-2676. [Pg.153]

Dominski Z Nucleases of the metallo-beta-lactamase family and their role in DNA and RNA metabolism. Grit Rev Biochem Mol Biol 2007, 42(2) 67—93. [Pg.161]

Epstein L, Hunter JC, Arwady MA, Tsai V, Stein L, Gribogiannis M, Frias M, Guh AY, Laufer AS, Black S, Pacilli M, Moulton-Meissner H, Rasheed JK, Avillan JJ, Kitchel B, Limbago BM, MacCannell D, Lonsway D, Noble-Wang J, Conway J, Conover C, Vernon M, Kallen AJ. New Delhi metallo-beta-lactamase-producing carbapenem-resistant Escherichia coli associated with exposure to duodenoscopes. Jama-J Am Med Assoc. 2014 312(14) 1447-55. [Pg.172]

Comaglia G, Akova M, Amicosante G. Metallo-beta-lactamases as emerging resistance determinants in Gram-negative pathogens open issues. Int J Antimicrob Agents. 2007 29 380-8. [Pg.314]

Bush K. 1998. Metallo-beta-lactamases a class apart. Clin Infect Dis 27 S48-S53. Siemann S, Brewer D, Clarke AJ, Dmitrienko GI, Lajoie G, Viswanatha T. 2002. lMP-1 metallo-beta-lactamase effect of chelators and assessment of metal requirement by electrospray mass spectrometry. Biochim Biophys Acta 1571 190-200. [Pg.391]

Garrity JD, Pauff JM, Crowder MW. 2004. Probing the dynamics of a mobile loop above the active site of LI, a metallo-beta-lactamase from Stenotrophomonas malto-philia, via site-directed mutagenesis and stopped-flow fluorescence spectroscopy. J Biol Chem 279 39663-39670. [Pg.391]

Garau G, Di Guilmi AM, Hall BG. 2005. Structure-based phylogeny of the metallo-beta-lactamases. Antimicrob Agents Chemother 49 2778-2784. [Pg.391]

Cricco JA, Orellano EG, Rasia RM, CeccarelU EA, Vila AJ. 1999. Metallo-beta-lactamases does it take two to tango . Coord Chem Rev 190-192 519-535. [Pg.391]

Schilling O, Wenzel N, Naylor M, Vogel A, Crowder M, Makaroff C, Meyer-Klaucke W. 2003. Flexible metal binding of the metallo-beta-lactamase domain glyoxalase II incorporates iron, manganese, and zinc in vivo. Biochemistry 42 11777-11786. [Pg.392]

Wenzel NF, Carenbauer AL, Pfiester MP, Schilling O, Meyer-Klaucke W, Makaroff CA, Crowder MW. 2004. The binding of iron and zinc to glyoxalase II occurs exclusively as di-metal centers and is unique within the metallo-beta-lactamase family. J Biol Inorg Chem 9 429-438. [Pg.392]

Garcia-Saez I, Mercuri PS, Papamicael C, Kahn R, Frere JM, Galleni M, RossoUni GM, Dideberg O. 2003. Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril. J Mol Biol 325 651-660. [Pg.392]

Garrity JD, Bennett B, Crowder MW. 2005. Direct evidence that the reaction intermediate of metallo-beta-lactamase LI is metal hound. Biochemistry 44 1078-1087. [Pg.392]

Gomes CM, Frazao C, Xavier AV, LeGall J, Teixeira M. 2002. Functional control of the hinuclear metal site in the metallo-beta-lactamase-like fold by subtle amino acid replacements. Protein Sci 11. IQl—l 12. [Pg.393]

J. Antony, J. P. Piquemal, and N. Gresh, /. Comput. Chem., 26(11), 1131-1147 (2005). Complexes of Thiomandelate and Captopril Mercaptocarboxylate Inhibitors to Metallo-Beta-Lactamase by Polarizable Molecular Mechanics Validation on Model Binding Sites by Quantum Chemistry. [Pg.76]

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