Ocular toxicity lacrimators

Trifluralin is classified as a Toxicity Category IV (practically nontoxic) agent for acute oral toxicity and dermal irritation and Toxicity Category III (slightly toxic) for acute dermal toxicity, acute inhalation toxicity, and eye irritation. Ocular irritation is characterized by increased lacrimation, photophobia, and redness. Conjunctivitis can continue for 5-7 days. 

Highly toxic by oral, ocular, inhalation, and skin absorption routes exposure to 27 ppm/4 hr was lethal to mice following lacrimation and somnolence ocular and oral intake prodnced tremor, convulsion, coma, and death subcutaneous dose of 15 mg/kg was lethal to mice LD50 oral (mice) 10 mg/kg LD50 skin (rabbits) ... 

The eyes are a major target for the short-lived toxic effects of RCAs. Eye findings from RCA toxicity can range in severity from conjunctival erythema to ocular necrosis. Lacrimation, conjxmctival erythema/edema, blepharitis, and erythema are the most typical findings after exposure to all RCAs. Toxic signs may further include periorbital edema (Yih 1995), blepharospasm or spasms during eyelid closure (Grant, 1986 Blain, 2003), apraxia... 

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