Label-Based Electrochemical Nucleic Acid Biosensors

1 Label-Based Electrochemical Nucleic Acid Biosensors 

Label-based electrochemical nucleic acid hybridization biosensors work on the principle of the following groups  

Using redox active hybridization indicator which has an affinity for ss or ds DNA 

Using labeled signaling probes or labeled target DNA 

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Early studies on electrochemical nucleic acid biosensors were based on electrochemical transduction of redox labels (indicators) that have significant different behaviors between dsDNA and ssDNA. These intercalator molecules have higher binding affinity to dsDNA than ssDNA. Mikkelsen and coworkers investigated this approach by using Co(phen) as a hybridization indicator. The intercalator molecule was accumulated at ss and dsDNA at covalently attached... 

The topics discussed in the book include electrochemical detection of DNA hybridization based on latex/gold nanoparticles and nanotubes nanomaterial-based electrochemical DNA detection electrochemical detection of microorganism-based DNA biosensor gold nanoparticle-based electrochemical DNA biosensors electrochemical detection of the aptamer-target interaction nanoparticle-induced catalysis for DNA biosensing basic terms regarding electrochemical DNA (nucleic acids) biosensors screen-printed electrodes for electrochemical DNA detection application of field-effect transistors to label-free electrical DNA biosensor arrays and electrochemical detection of nucleic acids using branched DNA amplifiers. 

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