L-tert.-Butylamino

Timolol Timolol is l-(tert-butylamino)-3-[(4-morphohne)-l,2,5-thiadiazol-3-yl)oxy]-2-propanol (12.1.10) [19-27]. 

CTnJ< H9C -Li 1. Toluol/Hexan 0°, 2h l-tert.-Butylamino- 1-phenyl- 90 1... 

Chemical Name l-(tert-Butylamino)-3-[2-[(tetrahydro-2-furanyl)methoxy] phenoxy]-2-propanol... 

Cyclopropan l-tert.-Butylamino-2,2-dimethyl-l-methoxy- E17b, 1604 (2-Hal —imin + R — OH) Decansanre -amid IV/la, 401 Essigsaure... 

Diethy lamino-2-hyd roxy-1 -phenyl-E16d, 1124 (Oxiran + Amin) 2-Propanol l-tert.-Butylamino-l-phenyl- E21e, 5376 (En + OjOs=NR Red.)... 

Step D Chemical Reduction Preparation of 3-Morpholino-4-(3-tert-Butylamino-2-Hydroxy-propoxyl-l,2,5-Thiadiazole — The 3-morpholino-4-(3-tert-butylamino-2-oxopropoxy)-1,2,5-thiadiazole (0.01 mol) is dissolved in isopropanol (10 ml). To the solution is added sodium borohydride in portions until the initial evolution of heat and gas subsides. The excess sodium borohydride is destroyed by addition of concentrated hydrochloric acid until the mixture remains acidic. The precipitate of sodium chloride is removed, ether is added, and the solution is concentrated to crystallization. The solid material is removed by filtration and dried thus providing 3-morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole, MP 161° to 163°C (as hydrochloride). 

I -Phenyl-pyrrolidin + 4-Anilino-butanol l -tert.-Butyl-pyrrolidin + 4-terl.-Butylamino-butano ... 

Schwesingefs phosphazene base 2-tert-butylamino-2-diethylamino-l,3-dimethyl-perhydro-l,3,2-diazaphosphorine (PS-BEMP has a pKb = 27.5 in MeCN) has been immobilized and shown to have immense utility in the N- and O-alkylation of many weakly acidic heterocycles. Kim et al. has made extensive use of this reagent in the multi-step synthesis of a small collection of guanines possessing potential antiviral activity [90]. The generic procedure involved the direct alkylation of the purine moiety (20) (Scheme 2.64), promoted by PS-BEMP, resulting in a mixture... 

Auf die Umwandlung von Nitro-aliphaten zu Carbonsauren [E5, 207 (1985) VIII, 441 (1952), X/l, 456-458 (1971)] bzw. Carbonsaure-Derivaten, z.B. Carbonsaure-amiden [s.E5, 936 (1985)] Oder N-Acyl-hydroxylaminen [s.E5, 1142/43 (1985)] sei verwiesen. Die Umsetzung von primaren Nitro-aliphaten mit tert.-Butylamino-magnesiumbromid fuhrt in Tetrahydrofuran in befriedigenden Ausbeuten (40-45%) zu Hydroxamsaure-amiden (Carbonsaure-amid-hydroximiden) (40—45%) ... 

C(CH,)3 C(CH,), C(CH,), CH3 C(CH3)3 2- tert.-Butylamino-l-( l,3-dithian-2-yl)- 3,3-dimethyl-Toxo-butan 3- ( 1-Adamantyl-amino) -4,4-dimelhyl-2- oxo-nentan 4- ( l-Adamantyl-aminoj-5,5-dimethv/-3- oxo-hexan 58 65 69... 

Chemical Name 5-(2-(tert-Butylamino)-l-hydroxyethyl)-m-phenylene bis(dimethylcarbamate)... 

Chemical Name l(2H)-Naphthalenone, 3,4-dihydro-5-((2S)-3-(tert-butylamino)-2-hydroxypropoxy)-, hydrochloride... 

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