L- phcnyl

Nitroso-arene lassen sich mit 4-(Dichloramino)-tetrafluor-pyridin zu den l-Phcnyl-2-(tetrafluor-4-pyridyl)-diazen-l-oxidenkondensieren. Diese Methode liefert unsym-metrische Azoxy-Verbindungen sie wird bes. zur Herstellung aliphatischer Azoxy-Verbindungen verwendct (vgl. S. 35). Die Ausbeuten betragen 30-56% bei Katalyse mit Kup-fer(I)-chlorid ... 

Sulfurane Bis-[4-tert.-bulyl-phenyl]-bis-[l-phcnyl-2,2,2-trifluoro-l-Irifluoromethyl-etlioxy]- Ella. 667 (Ar2S + R —OK)... 

What product would you expect from the rooctiron of l-phcnyl-2-biitejie with NBS Explain. 

A mixture of 8 mg (0.01 mmol) of PdCl2[(R)-BlNAP] and 1 g (4 mmol) of l,l-dichloro-1-phenyl-2,2,2-trimethyldisilane in 2mL of benzene is stirred for 15 min under nitrogen. To the resulting clear yellow solution is added 0.29 g (2 mmol) of ( )-l-phcnyl-2-butcnonc. The mixture is heated under reflux for 2 h the progress of the disilylation can be monitored by GLC. 2mL of diethyl ether is added, the mixture is cooled to —70 °C and 6.2 mL of a 1.9 M solution (12 mmol) of methyllithium in diethyl ether is added. The mixture is stirred at - 70 °C for 10 min then quenched with dilute hydrochloric acid. Extraction with diethyl ether followed by preparative TLC (silica gel, hexane/diethvl ether 5 1) gives the product yield 0.41 g (72%) [a]jy° 11.2 (c = 1.3. CHC1,). 

Oxo- l-phcnyl-2-(4-amino-phenyl)- 529 1 -Oxo- l-phenyl-2-(4-nitro-phenyl)- 529... 

The, g 7M-dibroniodihydrocyclopropa[r]isoqiiinolines 8 (R = H, Cl), prepared by addition of dibromocarbene to the corresponding 2-acctyl-l-phcnyl-l,2-dihydroisoquinolines, in the presence of silvcr(I) trifluoioacetate, undergo rearrangement to the 5/f-2-bcnzazepines 9, albeit in poor yields.3... 

In asymmetric Strecker synthesis ( + )-(45,55 )-5-amino-2,2-dimethyl-4-phenyl-l,3-dioxane has been introduced as an alternative chiral auxiliary47. The compound is readily accessible from (lS,25)-2-amino-l-phcnyl-l,3-propancdioI, an intermediate in the industrial production of chloramphenicol, by acctalization with acetone. This chiral amine reacts smoothly with methyl ketones of the arylalkyl47 or alkyl series48 and sodium cyanide, after addition of acetic acid, to afford a-methyl-a-amino nitriles in high yield and in diastereomerically pure form. 

The Michael additions of chiral cycloalkanone imines or enamines, derived from (FV l-l-phcnyl-ethanamine or (5)-2-(methoxymethyl)pyrrolidine, are highly diastereofacially selective reactions providing excellent routes to 2-substituted cycloalkanones. This is illustrated by the addition of the enamine of (S)-2-(methoxymethyl)pyrrolidine and cyclohexanone to 2-(aryl-methylene)-l,3-propanedioates to give, after hydrolysis, the (2 5,a.S )-oxodicstcrs in 35-76% yield with d.r. (2 S,aS)/(2 S,a/ ) 94 6- > 97 3 and 80-95% ee214. 

Diphenyl-4,5-dihydro-l,2-oxazol —> cis-3-Phcnyl-2-benzyl-aziridin 31% d.Th. 

Brom-l-allyloxy- 401 2-Brom-l-[cyclopenten-(3)-yl]- 401 2-Brom-l-oxo-l-(4-brom-phenyl)- 308, 503, 510 2-Brom-l-oxo-l,2-diphenyI- 569 2-Brom-l-oxo-l-phenyl- 396, 492, 503, 533, 621 2-Brom-l-phcnyl- 389, 520... 

Brom-397, 400, 402, 510, 512, 520 3-(2-Brom-athoxy)- 401 3-Brom-l-phcnyl- 580 3-Chlor- 512, 672 3-ChIor-2-benzyl- 401 3-Chlor-2-methyl- 401 3-ChIor-2-methyl-l -phenyl- 401... 

CN [/ -(/ , R )]-2,2-dichloro-V-[2-hydroxy-l-(hydroxymethyl)-2-[4-(methylsulfonyI)phcnyl]ethyl]acetaniide... 

Methoxy-4-methyl-3-oxo-2-phenyl-3,4-dihydro-5,8-quinoxalinequinone 6-Methoxy-1 -methyl-3-phcnyl-2(l //)-quinoxalinone... 

Amino-phcnyl)-2-hydroxy-l,3,4-oxadiazol (R1 =2-NH2 R2 = H)179 1,11 g (0,005mol) Kohlensiiure-[2-(2-amino-benzoyl)-hydrazid]-dimethylamid wind in 11 ml DMF gclost und 2 h unter RiickfluB erhitzt, ge-kiihlt, 50 m/Wasserzur Reaktionslosunggegebenund 1 him Eisbad belasscn. Manfiltricrt und kristallisiert die erhaltene Substanz aus Ethanol um Ausbeute 0,62 g (70%) Schmp. 174-175° (Ethanol/Wasser). 

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