2-Amino-3-benzoyl-6-

Other non-traditional preparations of 1,2,3-triazoles have been reported. The rearrangement in dioxane/water of (Z)-arylhydrazones of 5-amino-3-benzoyl-l,2,4-oxadiazole into (2-aryl-5-phenyl-27/-l,2,3-triazol-4-yl)ureas was investigated mechanistically in terms of substituents on different pathways <06JOC5616>. A general and efficient method for the preparation of 2,4-diary 1-1,2,3-triazoles 140 from a-hydroxyacetophenones 139 and arylhydrazines is reported <06SC2461>. 5-Alkylamino-] //-], 2,3-triazoles were obtained by base-mediated cleavage of cycloadducts of azides to cyclic ketene acetals <06S1943>. Oxidation of N-... 

Bei der Oximierung von 5-Amino-3-benzoyl-l,2,4-oxadiazol erhalt man 3-Phenyl-4-ureido-fu-razan110,111. 

DFT calculations have probed electronic effects in the reaction of 2-arylhydrazono acetic acid with pyruvic acid to give (2Z)- and (2 )-3-aryl acrylic acids. Rearrangement of 11 (Z)-arylhydrazones of 5-amino-3-benzoyl-l,2,4-oxadiazole to give 2-aryl-5-phenyl-(2//-triazol-4-yl)ureas has been studied in toluene, with catalysis by TEA or piperidine, and compared to earlier results in more polar media. The kinetics of the acetophenone-phenylhydrazine reaction has been studied for a variety of solvents and ketone ring substituents. ... 

The acid-catalysed rearrangement of benzyl phenolic ethers to diphenylmethane compounds and the rates of rearrangement of (Z)-aryUiydrazones of 5-amino-3-benzoyl-l,2,4-oxadiazole into (2-aryl-5-phenyl-2H-l,2,3-triazol-4-yl)ureas have been reported. ... 

Cosimelli, B., Frenna, V., Guemelli, S., Lanza, C.Z., Macaluso, G., Petrillo, G., Spinelli, D. The first kinetic evidence for acid catalysis in a monocyclic rearrangement of heterocycles conversion of the Z-phenylhydrazone of 5-amino-3-benzoyl-... 

Chemical Name N-[4-[ [(2-amino-1,4-dihydro-4-oxo-6-pteridinyI)methyl] amino] benzoyl] -L-glutamic acid... 

Methyl-l W-l,3,4-benzotria/epine-2,5(3//,4//)-dione (20) and 3-Methyl-4-[2-(l-methylhydrazinocarbonyl-amino)benzoyl -1H-1,3,4-henzotriazepine-2,5(3/f,4//)-dione (21) Single Procedure 362... 

CN 4-[[4-[(aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester monomesylate... 

Cltrivorum factor (CF), folinic acid, and leuco-vorin are all N-[4[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]-amino]benzoyl]glutamic acid, I, the Leuconostoc citrovorum 8081 growth factor first reported by Sauberlich and Baumann.1 Leucovorin refers to the chemically synthesized material that contains both dL and 1L diastereomers "citrovorum factor" and "folinic acid" generally apply to the biologically synthesized 1L isomer. 

Amino-phcnyl)-2-hydroxy-l,3,4-oxadiazol (R1 =2-NH2 R2 = H)179 1,11 g (0,005mol) Kohlensiiure-[2-(2-amino-benzoyl)-hydrazid]-dimethylamid wind in 11 ml DMF gclost und 2 h unter RiickfluB erhitzt, ge-kiihlt, 50 m/Wasserzur Reaktionslosunggegebenund 1 him Eisbad belasscn. Manfiltricrt und kristallisiert die erhaltene Substanz aus Ethanol um Ausbeute 0,62 g (70%) Schmp. 174-175° (Ethanol/Wasser). 

The first clinically tested ADEPT prodrug, 4-[(2-chloroethyl)(2-mesy-loxyethyl) amino]benzoyl-L-glutamic acid (CMDA), is converted in vivo to the cytotoxic parent drug 4-[(2-chloroethyl)[2-(mesyloxy)ethyl]amino]ben-zoic acid, as shown in Fig. 3.15. 

Examples Toluidines, nitroanilines, amino benzoyl amides, and the sulfonic acids thereof. 

GLUTAMIC ACID, N-(p- (((2-AMIN0-3.4,5,6.7.8-HEXAHYDRO-4-OXO-6-PTERIDINYL)METHYL) AMINO) BENZOYL) -. L-... 

Chemical Name L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl) amino)benzoyl)-, hydrate... 

A sirupy pentapropionate of L-sorbose was described by Hurd and Gordon.142 Crystalline esters of L-sorbose, such as the 1-benzoyl-,55 1-p-aminobenzoyl-148 and 1-tosyl-, 144,56 have also been synthesized. 1-p-Aminobenzoyl-L-sorbose was prepared as a possible substance for measuring the rate of glomerular filtration. It was synthesized by esterifying 2,3 4,6-diisopropylidene-L-sorbose with p-nitrobenzoyl chloride, with subsequent reduction of the nitrobenzoyl ester to 1-p-amino-benzoyl-2,3 4,6-diisopropylidene-L-sorbose. Removal of the isopropyli-dene groups by dilute acid hydrolysis furnished the desired product. 1-Tosyl-L-sorbose was independently prepared by two different methods. The first method,55 discussed on page 110, involves the oxidation of a properly substituted sorbitol derivative, while the latter method144 is similar to the one used for the preparation of the 1-p-aminobenzoyl derivative, namely esterification of 2,3 4,6-diisopropylidene-L-sorbose, followed by acid hydrolysis. This cyclic acetal has also been esterified to the crystalline l-mesyl-2,3 4,6-diisopropylidene-L-sorbofuranose by... 

CN /V-[4-ff(2-amino-5-formyl-l,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino]benzoyl -].-glutamic acid... 

Aluminum Identification Test, 753 Aluminum Magnesium Silicate, 41 Aluminum Potassium Sulfate, 21 Aluminum Sodium Sulfate, 21 Aluminum Sulfate, 22 Ambrette Seed Liquid, 23 Ambrette Seed Oil, 23, 596 Aminoacetic Acid, 186 A-[4-[[(2-Amino-l,4-dihydro-4-oxo-6-pteridinyl)methyl] amino] benzoyl] -l-glutamic Acid, 157 3 - Amino-7-dimethylamino-2-methylphenazine Chloride, 861 L-2-Aminoglutaramic Acid, 175 L-2-Amino-5-guanidinovaleric Acid, 32, (S3)5... 

Difluoro-4-[bis(2-iodoethyl)amino]benzoyl-L-glutamic acid, (III), prepared by Springer (2) was effective as an alkylating agent and used in treating cells lines associated with breast cancer. 

These two groups of compounds have different mechanisms for inducing sterility. The antimetabolites have been considered as compounds wherein a metabolite essential to cell development has been changed in one or several ways and, when introduced into an animal, will elicit signs associated with a specific lack of the metabolite (10y 11). Some of the more promising are methotrexate, aminopterin (N- p- [ (2,4-diamino-6-pteridyl)methyl]amino benzoyl glutamic acid), 5-fluorouracil, and S-fluoro-orotic acid. 

SYNS KETONE, m-(BIS(2-CHLOROETHYL)AMINO)PHENYL PIPERIDINO PIPERIDINE, l-(m-(BIS(2-CHLOROETHYL)-AMINO)BENZOYL)-... 

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