3-Ethyl-5-phcnyl

CN (+)-iV-[3- 1 -hydroxy-2-(methylamino)ethyl]phcnyl]methanesulfonamide monomethanesulfonate amidephrine... 

Chlor-diphenyl- E2, 11-18, 22, 77-78, 139, 161, 211, 224, 229, 237, 240, 241, 280, 281, 288, 289, 290, 297, 298. 865 (2-Chlor-ethoxy)-dichlor- E2, 151 (2-ChJor-cthoxy)-hydroxy-methyI- E2, 186 (2-Chlor-ethyl)-dichlor- E2, 192 (2-Cblor-ctbyl)-methyl-trimcthylsilyloxy- E2, 209 Chlor-ethyl-isopropylthio- E2, 222 Chlor-ethyl-phcnyl- E2, 211, 280 Chlor-ethyl-2-thienyl- E2, 9, 10 Chlor-(4-methoxy-phenyl)-phenyl- E2, 290 Cblormethyl-dichlor- E2, 157, 158, 474 (4-Ch(or-phenyl)-dichlor- El, 192 (4-Chlor-phenyl)-diethyl- E2, 99 (4-Chlor-phenyl)-diethyl- -4-nitro-phenylimid E2, 99... 

Chlorcarbonyl-ethyl)-phenyl- -(2-chlor-l-chlor-methyl-ethylester) E2, 191 (2-Chlorcarbonyl-ethyl)-phcnyl- -chlorid E2, 157 (2-Chlorcarbonyl-l-methyl-ethyl)-ethyl- -chlorid E2, 157... 

Oxo-2-phenyl-ethyl)-phcnyl- E2. 137 [l-(2-Oxo-2-phenyl-ethyl)-3-phenyl-allylJ-... 

Ethyl l//-azepine-l-carboxylate (1) fails to react with simple dienophiles such as maleic anhydride and dimethyl acetylenedicarboxylate, even at 100 C 250 however, with /V-phcnyl-maleimide a [4 + 2] cycloadduct at the C2 — C5 diene system is produced.251... 

CN [/ -(/ , R )]-2,2-dichloro-V-[2-hydroxy-l-(hydroxymethyl)-2-[4-(methylsulfonyI)phcnyl]ethyl]acetaniide... 

A stirred solution of 13.0 g (100 mmol) of 5-oxohexanoic acid and 17.5 g of (1, S. 2.S )-2-amino-1-phcnyl-1,3-propanediol is heated under reflux in benzene for 16 h with azeotropic removal of water. The solution is concentrated and the residue is dissolved in 600 mL of diethyl ether. The solution is washed with sat. aq NH4C1, water, sat. aq Na2C03 and brine before drying over MgS04 and concentration in vacuo to give a colorless oil yield 24 g (96%) 84 14 2 mixture of isomers (the major isomers are diastereomers while the minor isomer is a regioisomer). Rccrystallization from ethyl acetate/hexane furnishes colorless needles yield 15.7g(60%) mp98-99°C [ ]D +13.3 (c = 1.1, ethanol). 

Versuche zur enantioselektiven Synthese von a-Aminosauren durch diastereoselektive Alkylierung des aus 2,4-Dioxo-3-[(7 )-l-phcnyl-ethyl]-imidazolidin mit Methoxycarbonyl-oxy-methyl-magnesium4 gebildeten Chelats blieben erfolglos Man erhalt ein 1 1-Dia-... 

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