Imidazole, l-

Methyl-1 -[2-(4-nitrophenyl)ethoxycarbonyl]-l//-imidazol-3-ium chloride, CH2CI2, DMAP, It, 100% yield. ... 

To a solution of methyl 3-oxobutanoate 127 (580 mg, 5 mmol) and l-methyl-2-methylthio-l//-imidazole-5-carboxaldehye 128 (390 mg, 2.5 mmol) in 5 mL of absolute methanol was added a solution of ammonium hydroxide (25%, 0.4 mL). The reaction was heated at reflux overnight before cooling to room temperature and removing the solvent. The crude product was purified by preparative TLC to afford 526 mg of dimethyl l,4-dihydro-2,6-dimethyl-4-(l-methyl-2-methylthio-5-imidazolyl)-3,5-pyridine-dicarboxylate 129 (60%) as a solid, mp = 200-201 °C (MeOH). 

Methoxy derivative was obtained from 2-(4,5-dihydro-l//-imidazol-2-yl)-7-hydroxy-8-methyl-2,3-dihydro-5//-pyrido[l,2,3- /e]-l,4-benzoxazin-5-one with methyl tosylate in DMF in the presence of K2CO3 at 50 °C for 1 h (99EUP894796). 

A/-cyano-A -methyl-/V"-[2-[[(5-methyl-l//-imidazol-4-yl)methyl]thio]ethyl]guanidine... 

CN 2-butyl-4-chloro-l-[[2 -(lH-tetrazol-5-yl)[l,r-biphenyl]-4-yl]methyl]-l//-imidazole-5-methanol monopotassium salt... 

CN 4-chloro-A-(4,5-dihydro-l//-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine... 

CN ( ()-l-[2-(Methylthio)-l-[2-(pentyloxy)phenyl]ethenyl]-l//-imidazole monohydrochloride... 

CN (2-chlorophenyI)[2-[2-[(diethylamino)methyl]-l//-imidazol-l-yl]-5-nitrophenyllmethanone fumarate (1 1)... 

CN (Z)-l-[2-I2-(4-chlorophenoxy)ethoxy]-2-(2,4-dichlorophenyl)-l-methylethenyl]-l//-imidazole mononitrate... 

CN (35-cij)-3-ethyldihydro-4-[(l-meihyl-l//-imidazol-5-yl)methyl]-2(3/f)-furanone monohydrochloride... 

C19H34N2O4 149550-86-7) see Eprosartan methyl 4-(acetylamino)-2-ethoxybenzoate (C12H15NO4 59-06-3) sec Mosapride citrate methyl acetylenecarboxylate (C4H4O2 922-67-8) see Rosoxacin methyl P-(acetyloxy)-2-butyl-l-[(4-carboxyphenyl)me-thyl]-a-(2-thienylmethyl)-l//-imidazole-S-propanoate (C2f,H3i)N20ftS) see Eprosartan... 

Based on gasliquidchromatography (GLPC) amides, formed from various enantiomeric amines and the chiral-derivatizing reagent ( S)-(—)-JV-pentafluorobenzoylprolyl-l-imidazole, could be detected at nanogram levels [43],[44]... 

The central piperazine core of 396 has been synthesized from reaction of 2-bromobenzofuran-3-one 394 and l-methyl-l//-imidazole-2-carboxamide 395 in acetonitrile at elevated temperatures (Equation 106) <1999H(50)259>. 

Imidazole, 1 -[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)-methoxy]-ethyl]. l-[2-(2,4-Dichlorophenyl)-2-(2,4-dichlorobenzyloxy)-ethyl]-l//-imidazole. l-[2,4-Dichloro-/ -(2,4-dichlorobenzyloxy)-phenethyl]-l//-imidazole. 

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