Imidazol-4-yl, l-

With stirring and under reflux, 8.6 g (0.053 mole) of imidazol-4-yl acetic acid hydrochloride, 7.1 ml of 85% phosphoric acid and 25 ml of chlorobenzene are heated to 100°C. Then 13.9 ml of phosphorus trichloride are added dropwise at 100°C, whereupon evolution of gas occurs. Over the course of 30 min a dense mass precipitates from the reaction mixture. The batch is heated for 3 hours to 100°C and the supernatant chlorobenzene is removed by decantation. With stirring and under reflux, the residual viscous mass is heated to the boil for 3 hours with 40 ml of 9 N hydrochloric acid. The batch is filtered hot with the addition of carbon and the filtrate is diluted with acetone, whereupon the crude 2-(imidazol-4-yl)-l-hydroxy-ethane-l,l-diphosphonic acid precipitates. This product is recrystallised from water. Melting point 238-240°C (dec.). 

A subsequent reaction with benzaldehyde gave 1-[1-(dimethylsulfamoyl)imidazol-4-yl]-l-phenylmethanol (83%). 

A/-cyano-A -methyl-/V"-[2-[[(5-methyl-l//-imidazol-4-yl)methyl]thio]ethyl]guanidine... 

US patent 6,734,308, Crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynyl-phenyl)-l-methyl-lH-quinolin-2-one, 2,3,-dihydroxy-butanedioate salts and method of production [108]. The invention relates to crystal forms of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-meth-yl]-4-(3-ethynyl-phenyl)-1 -methyl-lH-quinolin-2-one, 2,3-dihydroxy butanedioate salts, and to pharmaceutical compositions containing the above compound, methods of treating hyperproliferative diseases, such as cancers, in mammals, especially humans by administering the above compound, and to methods of preparing the crystal forms of the above compound and related compounds. 

Histidine His H 2-Amino-3-(l//-imidazol-4-yl)propanoic acid CHi- C - COOH... 

A domino reaction of 1,1-diphenyl-3,3-dilithioallene (157) with benzonitrile yields both a yellow imidazole (158 R = Ph X = NH) (12%) and a colourless 5-imidazol-5-yl-l,4-dihydropyrimidine (159 R = Ph) (51%), the products, respectively, of the incorporation of three and four nitrile molecules. The proposed mechanism (Scheme 13) involves initial formation of an intermediate (160) that is the product of the interaction of three molecules of benzonitrile with l,l-diphenyl-3,3-dilithioallene (157), which cyclizes to (162 R = Ph) and then eliminates a molecule of benzonitrile to produce (161 R = Ph). Re-addition of benzonitrile at a different locus produces... 

This enzyme [EC 4.2.1.19] catalyzes the conversion of D-eryrfiro-l-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate and water. 

Reaction of unsaturated 5(4//)-oxazolones with appropriate nucleophiles affords new unsaturated 5(4//)-oxazolone analogues used as intermediates to prepare a variety of interesting compounds. 4-(Chloromethylene)-5(4/i/)-oxazolones react with a variety of nucleophiles. For example, 4-(chloromethylene)-2-phenyl-5(4F/)-oxazolone 395 reacts with imidazole to afford 4-[(imidazol-l-yl)methyl-ene]-2-phenyl-5(4F/)-oxazolone 396. The authors found no evidence for the product derived from carbon-carbon bond formation, that is, 4-[(imidazol-4-yl)methylene]-2-phenyl-5(4//)-oxazolone (Scheme 7.126). 

Chemical Name lH-Pyrido[4,3-b]indol-l-one, 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-lH-imidazol-4-yl)methyl]-, monohydrochloride... 

Benzyl-2-methyl-l H-imidazol-4-yl)-5-(2-methyl-[l, 3]dioxolan-2-yl)-pentan-l -one... 

C ,H2 0, 85458 25 9) see Retinol (3,V-frans)-3-(2,5-dimcthoxy-3,4,6-trimcthylplicnyl)-l-(hexahydro-2-phcnyl-l /-pyrrolo(l,2-c imidazol-3-yl)-l-propanone... 

Preparation of 5-(2-bromo-3,5-dimethyl-3H-imidazol-4-yl)-3-methyl-[l,2,4]-oxadiazole... 

Preparation of 2-(l- 4-[4-(benzyloxy)phenyl]butyl -lH-imidazol-2-yl)-l-ethanol... 

Treatment of different substituted indoles 732 with commercially available l-acetylimidazolidin-2-one 733 in the presence of phosphoms oxychloride afforded after hydrolysis in ethanol the corresponding C-connected 3-(4,5-dihydro-l//-imidazole-2-yl)-l//-indoles 734 in moderate to good yields (Equation 173) <2001TL5187>. 

Beginning with 6-methyl-2-oxo-4-phenoxy-3-[(benzyl-carbonyl)amino]-l,2-dihydropyridine-1-acetic acid, (I), a method for preparing (R)-N-borono[3-(lH-imidazol-4-yl)propyl]methyl]-3-[(benzyl-carbonyl)amino]-6-methyl-2-oxo-4-phenoxy-1,2-dihydropyridine-l-acetamide HCl, (II), as illustrated in Eq. I, is described by the author in the current invention. 

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