Kuriyan, John

C-terminal tail (Tyr 527 in c-Src). Phosphorylation of Tyr 419 activates the kinase phosphorylation of Tyr 527 inhibits it. Crystal structures of a fragment containing the last four domains of two members of this family were reported simultaneously in 1997—cellular Src by the group of Stephen Harrison and Hck by the group of John Kuriyan. The two structures are very similar, as expected since the 440 residue polypeptide chains have 60% sequence identity. The crucial C-proximal tyrosine that inhibits the activity of the kinases was phosphorylated in both cases the activation loop was not. 

David S. Eisenberg John Kuriyan Frederic M. Richards... 

Krzysztof Kuczera (Harvard University), John Kuriyan, and Martin Karplus Molecular Dynamics of Myoglobin. ... 

Thomas Schindler, William Bornmann, Patricia Pellicena, W. Todd Miller, Bayard Clarkson and John Kuriyan, Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase. Science, 289 (2000), 1938-1942. 

JOHN KURIYAN Department of Molecular Biophysics Howard Hughes Medical Institute Rockefeller University New York, New York... 

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