Harrison, Stephen

Subsequently Stephen Harrison s group determined the x-ray structure of a PPRl-DNA complex and showed that the zinc cluster domain of PPRl and its mode of binding to DNA was very similar to that of GAL4, and that PPRl also dimerized through a coiled-coil region. However, the linker region... 

C-terminal tail (Tyr 527 in c-Src). Phosphorylation of Tyr 419 activates the kinase phosphorylation of Tyr 527 inhibits it. Crystal structures of a fragment containing the last four domains of two members of this family were reported simultaneously in 1997—cellular Src by the group of Stephen Harrison and Hck by the group of John Kuriyan. The two structures are very similar, as expected since the 440 residue polypeptide chains have 60% sequence identity. The crucial C-proximal tyrosine that inhibits the activity of the kinases was phosphorylated in both cases the activation loop was not. 

The molecular basis for quasi-equivalent packing was revealed by the very first structure determination to high resolution of a spherical virus, tomato bushy stunt virus. The structure of this T = 3 virus was determined to 2.9 A resolution in 1978 by Stephen Harrison and co-workers at Harvard University. The virus shell contains 180 chemically identical polypeptide chains, each of 386 amino acid residues. Each polypeptide chain folds into distinct modules an internal domain R that is disordered in the structure, a region (a) that connects R with the S domain that forms the viral shell, and, finally, a domain P that projects out from the surface. The S and P domains are joined by a hinge region (Figure 16.8). 

Polycyclic Fluoroaromatic Compounds. III. Octafluoro-acenaphthylene, and Decafluoro-indane, -acenaphthene, -anthracene, and -pyrene, D. Harrison, M. Stacey, R. Stephens, and J. C. Tatlow, Tetrahedron, 19(1963) 1893-1901. 

Doyle, Stephen J. and Maggie Harrison, Lost in Lillipuf http // www.northerneye.co.uk/sweep.htm (Reproduced from Health and Aging, April 1998 this article describes how Bonnet people see creatures wearing hats.)... 

Broadberry, Stephen, and Mark Harrison (eds.). The Economics of World War I, Cambridge University Press, 2005. 

Figure 5-40 Structure of a protein known as transcription factor NF-kB bound to its DNA target. Each subunit of the dimeric protein contains two (3 barrel domains. The loops at the ends of the barrels interact with the DNA in the center. From Muller et al.433 Courtesy of Stephen C. Harrison.

Finally, many thanks to Michael J. Harrison, M. Elena Lasterra-Sanchez, K. Gail Morris, Stephen P. Saberi, Matthew M. Salter, Gary J. Tustin, and K. Winky Young, who proof-read the manuscript. 

Daniel J. Harrison, Christopher M. Vogels and Stephen A. Westcott ... 

Ernest Hemingway edited by Scott Donaldson Homer edited by Robert Fowler Horace edited by Stephen Harrison Ibsen edited by James McFarlane Henry James edited by Jonathan Freedman Samuel Johnson edited by Greg Clingham Ben Jonson edited by Richard Harp and Stanley Stewart... 

OPENER Courtesy Aneel Aggarwal, Ph.D., and Stephen C. Harrison, Department of Biochemistry and Molecular Biology, Harvard University, from A.K. Aggarwal., et al.. Recognition of a DNA operator by the repressor of phage 434 A view at high resolution. Science 242, (11 November 1988) pp. 899-907. AAAS Fig. 10.20 ... 

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