Abelson tyrosine kinase

Fig. 3. A simplified illustration of BCR-ABL and SRC family kinase involvement in oncogenic signaling pathways. The inhibitory effect is indicated by the upside-down T s. ABL = Abelson tyrosine kinase BCR = breakpoint cluster region FAK = focal adhesion kinase Grb-2 = growth factor receptor-bound protein 2 HcK = hematopoietic cell kinase JNK = Jun amino-terminal kinase P = phosphate group PI3 K = phosphatidylinositol-3-kinase SFK = SRC family kinases StatS = signal transducer and activator of transcription 5. (Reprinted with permission from Ref (123)). 

Schindler T, Bornmann W, Pellicena P et al. Structural mechanism for STl-571 inhibition of abelson tyrosine kinase. Science 2000 289 1938-1942. 

Schindler, T., Bornmann, W., Pellicena, P., Miller, W. T., Clarckson, B., Kuriyan, J. (2000) Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase. Science 289,1938-1942. 

Schindler, T. Structural Mechanism of STI-571 Inhibition of Abelson Tyrosine Kinase. Science. 2000, 289, 1938-1942. 

T. Schindler, W. Bornmann, P. Pellicena, W.T. Miller, B. Clarkson, J. Kuriyan. Stmctural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science, 289, 1938, 2000. 

Elkins, T., Zinn, K., McAllister, L., Hoffmann, F.M. and Goodman, C.S. (1990b) Genetic analysis of a Drosophila neural cell adhesion molecule interaction of fasciclin I and abelson tyrosine kinase mutations. Cell 60 565-575. 

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