Kumada cross-coupling reactions, palladium metallic catalysts

Other successful examples of catalysts containing NHC ligands are found in palladium- and nickel-catalyzed carbon-carbon bond formations. The catalyst development with these metals has focused in particular on Heck-type reactions, especially the Mizoroki-Heck reaction itself [Eq. (42)] and various cross coupling reactions [Eq. (43)], e.g., the Suzuki-Miyaura reaction ([M] = and the Kumada-Corriu reaction ([M] = MgBr). " Related reactions like the Sonogashira coupling [Eq. (44)]326-329 Buchwald-... 

The metal-catalyzed cross-coupling of Grignard reagents with organylhalides is mostly referred as "Kumada reaction". In most cases. Nickel catalysts have been employed, but they are not subject of this chapter. However, there are many cases based on the pioneering works of Sekiya and Ishikawa, Kumada and Hayashi, where palladium complexes are used with success " (Scheme 5-102, Scheme 5-103, Experimental Procedure below ). The POPd2 system (see also Figure 5-12) delivers... 

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