Kollidon products

The soluble Kollidon products form reversible complexes with many hydrophobic active substances, and clear solutions in water are thus obtained. This may be affected by the molecular weight. The longer the chains or the higher the -value of the Kollidon type are, the stronger the solubility effect is, and thus the greater the solubility that can be obtained by the active substance. In practice, this effect was mostly exploited for the solubilization of antibiotics in human and veterinary medicine. There are also restrictions on the use of this substance in human parenter-als. In many countries the -value must not exceed 18, and there is also a restriction on the amount to be used for each dose administered in intramuscular application. 

Active substances can also be solubilized by Lutrol F 68 in addition to the Cremophor and Kollidon products. The... 

Fig. 3 Hardness of lactose tablets containing various Kollidon products (wet granulation)... 

Active substances can also be solubilized by Lutrol F 68 in addition to the Cremophor and Kollidon products. The mechanism is probably based, for the most part, on the principle of hydrophilization. Micelle formation is certainly of minor significance, if it exists at all. 

The effect of low-density micronized crospovidone (e.g. Kollidon CL-M) in stabilizing suspensions can also be partly explained in terms of Stokes law Its particle size is very fine (see Section 3.2.2), its bulk density low and its density in water also low as a result of swelling. The product differs in these properties from the coarser products and other micronized types which have a higher bulk density with a similar swelling volume, and make it useful as an auxiliary for oral and topical suspensions for reducing sedimentation and improving redispersibility [98]. The same applies, whether the commercial product is a suspension or a dry syrup, or instant granules from which the patient prepares an oral suspension. 

BASF product literature Luviskol PVP Polymers and Kollidon PVP Polymers. 1993. 

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