Kinetoplast DNA replication

Pentamidine (Pentam 300) binds to DNA and may inhibit kinetoplast DNA replication and function. It also... 

Woodward, R. and Gull, K. (1990) Timing of nuclear and kinetoplast DNA replication and early morphological events in the cell cycle of Trypanosoma brucei. J. Cell Sci. 95 49-57. 

Ferguson M, Totri AF, Ward DC et al. In situ hybridization to the Crithidia fosciculata kinetoplast reveals two antipodal sites involved in kinetoplast DNA replication. Cell 1992 70(4) 621-9. 

Fei uson ML, Totri AF, Perez-Morga D et aL Kinetoplast DNA replication Mechanistic differences between Trypanosoma brucei and Crithidia fasciculata. J Cell Biol 1994 126(3) 631-9. 

Abu-Elneel K. The initiation of Kinetoplast DNA replication in trypanosomatids Specific protein-DNA interactions at the replication origin The Hebrew University of Jerusalem, 2002. 

Johnson CE, England PT. Changes in organization of Crithidia fasdculata kinetoplast DNA replication proteins durii the cell cyde. J Cell Biol 1998 143(4) 911-9. 

Onn I, Milman-Shtepel N, Shlomai J. Redox potential r ulates binding of universal minicircle sequence binding protein at the kinetoplast DNA replication origin. Eukaryot Cell 2004 3(2) 277-87. 

Liu Y, Motyka SA, Englund PT. Effects of RNA interference of Trypanosoma brucei structure-specific endonuclease-I on kinetoplast DNA replication. J Biol Chem 2005. 

The kinetoplast DNA of trypanosomes (Fig. 5-16) consists of thousands of catenated circular DNA molecules. Among these the smaller minicircles always contain the sequence GGGGTTGGTGTAat their origins of replication. The minicircles are individually removed from the mass prior to replication. The two progeny circles are then both recatenated into the mass.462... 

Klingbeil MM, Drew ME, Liu Y et al. Unlocking the secrets of trypanosome kinetoplast DNA network replication. Ptotist 2001 132(4) 255-62. 

Perez-Morga D. Englund PT. The structure of replicating kinetoplast DNA networks. J Cell Biol 1993 123(5) 1069-79. 

Kitchin PA, Klein VA, England PT. Intermediates in the replication of kinetoplast DNA minicircles. J Biol Chem 1985 260(6) 3844-51. 

Ntambi JM, England PT. A gap at a unique locadon in newly replicated kinetoplast DNA minicircles from Trypanosoma equiperdum. J Biol Chem 1985 260(9) 5574-9. 

Birkenmeyer L, Ray DS. Replication of kinetoplast DNA in isolated kinetoplasts from Crithidia fasciculata. Identifrcation of minicircle DNA replication intermediates. J Biol Chem 1986 261(5) 2362-8. 

Ryan KA, Englund PT. Replication of kinetoplast DNA in Trypanosoma equiperdum. Minicitcle H strand fragments which map at specific locations. J Biol Chem 1989 264(2) 823-30. 

Englund PT. The replication of kinetoplast DNA network in Crithidia fasciculata. Cell 1978 14 157-168. 

Avtahami D, Tz ti Y, Shlomai J. A single-stranded DNA binding protein binds the origin of replication of the duplex kinetoplast DNA. Proc Natl Acad Sci USA 1995 92(23) 10511-5. 

DNA replication in trypanosomatids also appears to differ significandy from that in higher eukaryotes, with only one of the six subunits typically found in the eukaryotic replication origin complex being identified. There are also substantial differences in the mitochondrial replication machinety, since the complexity of the kinetoplast DNA (the trypanosomarid equivalent of a mitochondrial genome) strucmre dictates an unusual replication mechanism. "... 

Sheline C, Melendy T, Ray DS. Replication of DNA minicircles in kinetoplasts isolated from Crithidia fasciculata Structure of nascent minicircles. Mol Cell Biol 1989 9(l) 169-76. 

Engel ML, Ray DS. The kinetoplast structure-specific endonuclease 1 is related to the 5 exo/endonu-dease domain of bacterial DNA polymerase I and colocalizes with the kinettqrlast topoisomerase II and DNA polymerase beta during replication. Proc Nad Acad Sd USA 1999 96(15) 8455-60. 

In eukaryotic cells, the replication of cytoplasmic DNA is more susceptible to the action of intercalating dyes than the replication of chromosomal DNA. Well-known examples of this selective efficiency are (a) action of ethidium bromide on the kinetoplast of the trypanosomes, and (b) action of acriflavine on the mitochondrial DNA in yeasts (leading to petite ctAonie mutants). Such dyes are now used to study the importance of cytoplasmic DNA during morphogenesis. 

Ch. Brach, E. Delain and G. Riou, Replicating covalently closed, circular DNA from kinetoplasts of Trypanosoma cruzi, Proc. Natl. Acad. Sci. U. S. A., 1972, 69, 1642-1646. 

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