Kinases streptomycin kinase

Streptidine kinase. Streptomycin 6-phosphotransferase. APH(6). ATP + streptomycin = ADP + streptomycin 6-phosphate. 

To what extent cell lines from the Immorto-Mouse are appropriate inner ear models and thus are useful for ototoxic studies is a matter of debate. On the positive side, the OC-k3 cell line displayed cisplatin-induced apoptotic cell death that was attenuated by inhibition of mitogen-activated protein kinase kinases [86, 87], HEI-OC1 cells were sensitive to gentamicin, streptomycin, cispla-tin, and acetaminophen/hydrocodon [40, 85], However, the HEI-OC1 cell line received some criticism lately, because of the absence of cell death in response to gentamicin [77, 88], These characteristics suggested that the ototoxin-sensitivity of HEI-OC1 depended on the culturing conditions, or that some cell batches had lost their sensitivity to AG-induced cell death. 

Sugiyama, M. Sakamoto, M. Mochizuki, H. Nimi, O. Nomi, R. Purification and characterization of streptomycin 6-kinase, an enzyme implicated in selfprotection of a streptomycin-producing micro-organism. J. Gen. Microbiol., 129, 1683-1687 (1983)... 

Heinzel, P. Werbitzky, O. Distler, J. Piepersberg, W. A second streptomycin resistance gene from Streptomyces griseus codes for streptomycin-3-phos-photransferase. Relationships between antibiotic and protein kinases. Arch. Microbiol., 150, 184-192 (1988)... 

Walker JB Possible evolutionary relationships between streptomycin and bluensomycin biosynthetic pathways Detection of novel inositol kinase and O Carbamoyltransferase activities. J Bacteriol 1990 172 5844-5651. 

Mannosidostreptomycin, a biologically active analog, according to a recent report. is not adenylated by a kinase capable of inactivating streptomycin. Intriguingly. adenosine, as well as the C-nucleoside formy-cin is a competitive inhibitor of ATP which serves as phosphate donor in the inactivation of kanamycin by a phosphorylase of aeruginosa. ... 

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