Ketonucleosides biological activity

Among the unsaturated ketonucleosides may be classified the disaccharide derivative 74, which is an analog of the biologically active compound 68c. The key intermediate for the synthesis of this unsaturated ketodisaccharide nucleoside was the partially protected, disaccharide nucleoside 73, which was prepared by two separate routes,56 Treatment of 73 with the Me2SO-acetic anhydride reagent for two days at room temperature afforded 7-[2,3-di-0-benzoyl-4-0-(3-0-benzoyl-2,6-di-deoxy - / - d - glycero - hex - 2 - enopyranosyl - 4 - ulose) - 6 - deoxy - / - d -glycopyranosyl]theophylline (74), isolated crystalline.56... 

Confirming the importance, for the biological activity,10-n of a keto group in the sugar moiety, the antiviral activity of some keto-C-nucleo-sides has also been reported.13 From this study, it was clear that the presence of a ketone group in these nucleosides, as in 4 -ketonucleoside 50a, gave a compound able to inhibit the replication of murine leukemia virus at nontoxic concentrations. 

Biological results published during the past ten years concerning the in vitro10 13 and in vivo14 15 activity of ketonucleosides themselves have... 

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