Acetic anhydride reagent

Nitric acid-acetic anhydride reagent has been used to synthesize N,N -Amitro-N,N -ethylenebisacetamide (58) from A, A -ethylenebisacetamide (57) the former is a secondary high explosive and a precursor to the powerful explosive ethylenedinitramine (Section 5.10). It is interesting to note that (58) is not formed when (57) is treated with nitric acid alone or with strong mixed acid. 

The unusual copper nitrate-acetic anhydride reagent reacted with acetyl-acetone itself to form bis-(3-nitro-2,4-pentanediono) copper(II) (V), the same compound prepared by Nyholm (18). A novel elaboration of this reaction was treatment of hydrated chromium (III) nitrate with acetylacetone in acetic anhydride to yield a mixture of mono- and dinitrochromiumacetylacetonate (XI and XII). 

Among the unsaturated ketonucleosides may be classified the disaccharide derivative 74, which is an analog of the biologically active compound 68c. The key intermediate for the synthesis of this unsaturated ketodisaccharide nucleoside was the partially protected, disaccharide nucleoside 73, which was prepared by two separate routes,56 Treatment of 73 with the Me2SO-acetic anhydride reagent for two days at room temperature afforded 7-[2,3-di-0-benzoyl-4-0-(3-0-benzoyl-2,6-di-deoxy - / - d - glycero - hex - 2 - enopyranosyl - 4 - ulose) - 6 - deoxy - / - d -glycopyranosyl]theophylline (74), isolated crystalline.56... 

Epoxide formation is nearly suppressed when massively subeti-tuted olefine, such as 2,2,4-trimethyl-3-hexene among others, ate subjected to the chromic oxide-acetic anhydride reagent,42 Cyclo-hexene yields primarily 2-cyclohexenone and cyclohexane- 1,2-dione777 although some cyclohexane oxide appears to bo formed also (Eq, 111). 

Nitro compounds, labelled with carbon-14, have been used during the polymerization of styrene (40). It has been shown that picric acid, which is rather an inefficient inhibitor, formally resembles p benzoquinone with this monomer. It becomes incorporated in the polymer but most of it is included in polystyrene of comparatively low molecular weight. Most of the combined picric add can subsequently be removed by treatment with trifluoro-acetic anhydride reagent, showing that the picric acid is not held in the polymer by carbon-carbon bonds. Further, it was shown, by isotope dilution analysis, that most of the picric add removed from the polymer by this treatment appeared as the add. 

Unless otherwise directed, accurately weigh the appropriate amount of the sample indicated in the table below, transfer it into a 250-mL glass-stoppered Erlenmeyer flask, and add 5.0 mL of pyridine-acetic anhydride reagent (mix 3 volumes of freshly distilled pyridine with 1 volume of freshly distilled acetic anhydride). 

Once all of the solutions have been prepared, use the following procedure. Pipette 5 ml of the acetic anhydride reagent solution into each of two oven-dried Erlenmeyer flasks, followed by pipetting 5 ml of the 2-butanol solution into only one of the flasks and mark it flask B. Stopper both flasks and mix thoroughly for at least 15 min. Carefully pipette 45 ml of H2O over 2 5 min and allow the flask to cool to ambient temperature (5 10 min). Add 5 drops of the indicator solution and titrate with the NaOH solution to the violet... 

A,B Natural products reagent (NP No. 28) —> UV-365nm C Acetic anhydride reagent (AA No. 1) —> UV-365iim... 

Wacker-Chemie GmbH http //www.wacker.de, Whittaker, Clark Daniels http //WWW. wcdinc. com Trade Name Synonyms Eastman Acetic Anhydride Reagent Grade [Eastman http //WWW. eastman. com]... 

Eastman Acetic Anhydride Reagent Grade. See Acetic anhydride... 

Eastman Acetic Anhydride Reagent Grade 203-569-5 y-Valerolactone 203-570-0 Succinic anhydride 203-571-6 Amoco MAN Maleic anhydride 203-572-1 Arconate PC-1000 Arconate PC-HP Jeffsol PC PCHP... 

However, the separation of the ketone from the dicyclohexylurea formed in the reaction is frequently a serious experimental problem. Use of phosphoric, phosphorous, or cyanoacetic acid in lieu of pyridinium trifluoroacetate gave inferior yields. Limited investigation of the dimethyl sulfoxide-acetic anhydride reagent has shown it to be superior in oxidations of triphenylsilyl-methylcarbinol, triphenylsilylethylcarbinol, and l,l-diphenylsila-2-cyclo-hexanol, giving the corresponding ketones in 60-70% yields (17, 24) since no separation problems are encountered. 

Add by pipette or burette (do not pipette by mouth) 15 ml acetic anhydride reagent and swirl to mix. 

Inososes apparently exist in the enediol form in alkaline solution 91 y 124) they readily reduce 2,6-dichlorophenol-indophenol (the ascorbic acid reagent). Inososes cannot be acetylated under alkaline conditions, such as obtain with the conventional pyridine - acetic anhydride reagent, because aromatization occurs. Esters of inososes are likewise aromatized when heated with pyridine or sodium acetate 56), The deoxynitroinositols of Grosheintz and Fischer are converted to diacetyl-5-nitroresorcinol by pyridine and acetic anhydride 33), Attempts to convert cyclitols to cyclo-hexenetetrols (e.g., conduritol) by ordinary procedures of dehydration also result in the introduction of three double bonds. 

Beltagy YA(1976) Citric acid-acetic anhydride reagent for determining some alkaloids and organic bases. Pharmazie 31 483 84... 

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