Keith Harris

The essential oil of Eucalyptus dives contains L-piperitone and this provides a starting material for L-menthol using the process shown in Scheme 4.25. The L-piperitone is reduced to a mixture of piperitols, which are separated, and the major isomer, D-/ra j-piperitol, hydrogenated to give D-isomenthol containing a small amount of D-menthol. After purification, the former can be isomerized into L-menthol using aluminium isopropoxide as catalyst. About 30 tonnes per annum of l-menthol are produced by Keith Harris Co. in Australia using this route. 

The last synthesis of menthol which we will discuss, starts from /-piperitone which occurs in various species, especially peppermint. However, it is also a major component of Eucalyptus dives which made it an item of commerce in Australia. The Australian company, Keith Harris and Co, used to prepare /-menthol from this indigenous feedstock. The overall scheme is shown in Figure 4.27. 

Piperitone (194) can be extracted commercially form Eucalyptus dives. Reduction with lithium aluminium hydride gives a mixture of (—)-c -piperitol (190) (36%) and (-l-)-/ra 5-piperitol (191) (64%), which are then separated (237). The (-l-)-/ra/Js-piperitol is then hydrogenated over Raney-nickel to give [Pg.301]

Acknowledgement Helpful comments from Prof. Keith S. Murray and Prof. Harry Goodwin are acknowledged. HT is grateful for financial help from the Australian Research Council during his stay at Monash University (July-August 2002). Much of the SCO work was supported by the EC under TMR Network Contract No. ERBFMRXCT98-0199. 

Pfizer - Wade Blair, Blaise Lippa, and R. Keith Webber Schering-Plough - Joel Harris, Timothy Kowalski, and Anandan Palani... 

Chen, Y., Baker, R.E., Keith, K.C., Harris, K., Stoler, S., and Fitzgerald-Hayes, M. (2000) The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain. Mol. Cell. Biol. 20, 7037-7048. 

A great many of the authors cited in this paper were kind enough to supply us with collections of their reprints. In this regard thanks are due to Professors F. Bottomley, D. J. Cole-Hamilton, Glenn Crosby, Keith DeArmond, Jim Demas, Harry Goodwin, M.-A. Haga, John Kelly, A. B. P. Lever, A. Ludi, Tom Meyer and A. v. Zelewsky. 

Mewshaw RE, Edsall RJ Jr, Yang C, Manas ES, Xu ZB, Henderson RA, Keith JC Jr, Harris HA. ERbeta ligands 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem 2005 48 3953-79. 

Rowland Hansford John Gray Ben Harris N. Skau J.T. Kummer Dave Lipnick Keith Hall Robert Zabor Hugh Tobin R. Hal deman Mr. Starnes Don Mclver... 

A current trend in tertiary ethics training is to narrow the focus of ethics to applied ethics, or ethics for specific disciplines. The popular textbooks for ethics courses make this inclination obvious there are ethics texts for engineers (Harris et al. 2009), for psychologists (Koocher and Keith-Spiegel 1998), for social scientists (Israel and Hay 2006), for biologists (Laake et al. 2007 33-82), for clinical science disciplines (Emanuel et al. 2008), and for scientists in general (Committee on... 

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