Karas, Michael

The Laser Desorption Ionization (LDI) was investigated by Franz Hillenkamp and Michael Karas [2, 3], LDI involved sample bombardment with short and intense pulses from a laser light to effect both desorption and ionization of the analyte molecules. It has become a soft desorption ionization method for mass spectrometric analyses of biological macromolecules and small molecular compounds. The MALDI technique was improved by Koichi Tanaka. 

Koichi Tanaka presented experiments for soft laser desorption ionisation (SLD) of proteins in 1987. However, the predominant and most widely used version of SLD, matrix assisted laser desorption ionisation, MALDI, was introduced shortly afterwards by Michael Karas and Eranz Hillenkamp. Tanaka was awarded the Nobel Prize for his cornerstone invention in 2002. Prior to that, no method was available to transfer large biomolecules with molecular weights of more than... 

Andreas J0rgensen Michael Hauschild David Domfeld and Sami Kara ... 

Michael Hauschild David Domfeld, Margot Hutchins, Sami Kara and Francesco Jovane Management Engineering, Technical University of Denmark, Lyngby, Denmark University of California, Berkley, CA, USA Lawrence Livermore, Livermore, CA, USA School of Mechanical Manufacturing Engineering, The University of New South Wales, Sydney, NSW, Australia Dipartimento di Meccanica, Politecnico di Milano, Milano, Italy... 

Franz Hillenkamp, Thorsten W. Jaskolla, and Michael Karas... 

Michael Hanack Stephen Hanessian Shoji Kara Ronald G. Harvey Alfred Hassner Richard K. Haynes W. Christopher Hoffman... 

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