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Kallidin, Lysyl-Bradykinin

Bradykinin Kallidin (lysyl-bradykinin) desArg9-bradykinin desAig10-kallidin (Lys°, desArg9-bradykinin) T-kinin (Ile-Ser-bradykinin)... [Pg.673]

Kainate Receptor Kallidin, Lysyl-Bradykinin Kallikrein KCNQ-Channels KCOs... [Pg.1495]

Thi ,DPhe BK [Thi ,DPhe ]-bradykinin. bradykinin-potentiating peptide teprotide. bradykinin potentiator B teprotide. BRADYKININ RECEPTOR AGONISTS act at sites recognizing members and derivatives of the bradykinin family of hormone peptides - kinins - of which bradykinin (BK) and kallidin (lysyl-bradykinin Lys-BK KD) are the main mammalian members. The bradykinin family is distinct from the tachykinin family of peptides, though both have profound hypotensive actions and contract many intestinal and other smooth muscles. Historically, it was noted that the former action was relatively slow-developing, hence the name bradykinin. Notable actions of bradykinin and kallidin are to dilate blood vessels and increase their permeability to plasma proteins, and to stimulate sensory nerve C-fibres. These actions are pro-inflammatory, and reflect the fact that the kinin-formation system is activated in inflammation, and enzymes (kallikreins) form the kinins from blood-borne or tissue precursors (kininogens) on injurious insult. [Pg.54]

There are 3 known plasma kinins, namely the nonapeptide bradykinin or kallidin-9 [154, 157, 158, 363, 364, 473, 523], lysyl-bradykinin or kaUidin-10 [499,665] and methionyl-lysyl-bradykinin [155,159,556]. These pharmacologically active polypeptides behave simlarily, although quantitative differences exist between them [141, 156, 412]. Bradykinin increases vascular permeability in the rat after intradermal injection [82,107,167,633] and also after sub-plantar injection into the paw [110, 210, 389, 601], and as such plasma kinins are potential mediators of the anaphylactoid oedema. [Pg.356]

The name kinin in this text always refers to three distinct biologically active peptides nonapeptide bradykinin (nine amino acids), decapeptide kallidin (ten amino adds) and undecapepdde methionyl-lysyl-bradykinin (eleven amino adds). All other peptides will be characterized specifically. [Pg.359]

Lysyl-bradykinin (kallidin), which has an additional lysine residue at the V-terminal atoms can also be released. This kinin-releasing activity is present in all venoms of Crotalidae and Viperidae. [Pg.51]

The chemical structures of bradykinin, kallidin and methionyl-lysyl-brady-kinin ( = methionyl-kallidin) are shown in Figure 6. [Pg.361]


See other pages where Kallidin, Lysyl-Bradykinin is mentioned: [Pg.672]    [Pg.672]    [Pg.672]    [Pg.672]    [Pg.54]    [Pg.158]    [Pg.672]    [Pg.672]    [Pg.672]    [Pg.672]    [Pg.54]    [Pg.158]    [Pg.68]    [Pg.41]    [Pg.170]    [Pg.411]    [Pg.1115]    [Pg.195]    [Pg.343]    [Pg.313]   


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Bradykinin

Bradykinins

Kallidin

Lysyl

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